Taste masking of cefuroxime axetil by ion exchange resin complex

The antibiotic cefuroxime axetil is extremely bitter. The present study deals with development of taste-masked resinates of cefuroxime axetil using ion exchange resins. The drug resin complexation procedure was optimized with respect to drug to resin ratio and pH of medium. Taste masked complex was...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bhalekar, Mangesh R., Bidkar, Shital J., Shete, Tushar K., Madgulkar, Ashwini R.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia cefuroxime axetil; indion 214; ion exchange resin; suspension; taste masking Farmacología Medicamentos
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7889 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7889
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia cefuroxime axetil; indion 214; ion exchange resin; suspension; taste masking Farmacología Medicamentos
spellingShingle	Farmacia cefuroxime axetil; indion 214; ion exchange resin; suspension; taste masking Farmacología Medicamentos Bhalekar, Mangesh R. Bidkar, Shital J. Shete, Tushar K. Madgulkar, Ashwini R. Taste masking of cefuroxime axetil by ion exchange resin complex
topic_facet	Farmacia cefuroxime axetil; indion 214; ion exchange resin; suspension; taste masking Farmacología Medicamentos
description	The antibiotic cefuroxime axetil is extremely bitter. The present study deals with development of taste-masked resinates of cefuroxime axetil using ion exchange resins. The drug resin complexation procedure was optimized with respect to drug to resin ratio and pH of medium. Taste masked complex was characterized by FTIR, DSC and XRPD studies. In vitro release studies revealed complete drug release from the complex within 120 min in 0.1N HCl solution whereas less than 5 % drug was released from taste masked complex in 60 sec in simulated salivary fluid (pH 6.2) which found to be insufficient to impart bitter taste. The taste-masked complex was then formulated into a suspension dosage form using sodium carboxymethyl cellulose as suspending agent. The suspension was evaluated for various quality control parameters and in vivo studies were carried out to check bioavailability of drug from suspension.
format	Articulo Articulo
author	Bhalekar, Mangesh R. Bidkar, Shital J. Shete, Tushar K. Madgulkar, Ashwini R.
author_facet	Bhalekar, Mangesh R. Bidkar, Shital J. Shete, Tushar K. Madgulkar, Ashwini R.
author_sort	Bhalekar, Mangesh R.
title	Taste masking of cefuroxime axetil by ion exchange resin complex
title_short	Taste masking of cefuroxime axetil by ion exchange resin complex
title_full	Taste masking of cefuroxime axetil by ion exchange resin complex
title_fullStr	Taste masking of cefuroxime axetil by ion exchange resin complex
title_full_unstemmed	Taste masking of cefuroxime axetil by ion exchange resin complex
title_sort	taste masking of cefuroxime axetil by ion exchange resin complex
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7889 http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_6.pdf
work_keys_str_mv	AT bhalekarmangeshr tastemaskingofcefuroximeaxetilbyionexchangeresincomplex AT bidkarshitalj tastemaskingofcefuroximeaxetilbyionexchangeresincomplex AT shetetushark tastemaskingofcefuroximeaxetilbyionexchangeresincomplex AT madgulkarashwinir tastemaskingofcefuroximeaxetilbyionexchangeresincomplex
bdutipo_str	Repositorios
_version_	1764820486762528772

Taste masking of cefuroxime axetil by ion exchange resin complex

Ejemplares similares