Effects of rutin from leaves and flowers of buckwheat (Fagopyrum esculentum Moench.) on angiotensin II-induced hypertrophy of cardiac myocytes and proliferation of fibroblasts
Rutin was isolated from dried leaves and flowers of buckwheat (Fagopyrum esculentum Moench.). The effects of rutin on angiotensin II-induced hypertrophy of cultured cardiac myocytes and proliferation of cardiac fibroblasts of neonatal rats were evaluated by analyzing the cell surface area, measuri...
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Autores principales: | , , , , |
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Formato: | Articulo Comunicacion |
Lenguaje: | Inglés |
Publicado: |
2010
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Materias: | |
Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7883 http://www.latamjpharm.org/trabajos/29/1/LAJOP_29_1_2_5_D131M9W9AH.pdf |
Aporte de: |
Sumario: | Rutin was isolated from dried leaves and flowers of buckwheat (Fagopyrum esculentum
Moench.). The effects of rutin on angiotensin II-induced hypertrophy of cultured cardiac myocytes and
proliferation of cardiac fibroblasts of neonatal rats were evaluated by analyzing the cell surface area, measuring
the protein synthesis rate through 3H-leucine incorporation, and the MTT method. Rutin (0.8 to 8.0
mg/l) exhibited a strong inhibition on the hypertrophy and proliferation. The results suggested that rutin
from buckwheat flowers and leaves might have protective effects on cardiac hypertrophy. |
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