Effects of rutin from leaves and flowers of buckwheat (Fagopyrum esculentum Moench.) on angiotensin II-induced hypertrophy of cardiac myocytes and proliferation of fibroblasts

Rutin was isolated from dried leaves and flowers of buckwheat (Fagopyrum esculentum Moench.). The effects of rutin on angiotensin II-induced hypertrophy of cultured cardiac myocytes and proliferation of cardiac fibroblasts of neonatal rats were evaluated by analyzing the cell surface area, measuri...

Descripción completa

Detalles Bibliográficos
Autores principales: Han, Shu-Ying, Chu, Jin-Xiu, Li, Guang-Min, Zhu, Li-Sha, Shi, Rui-Fang
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2010
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7883
http://www.latamjpharm.org/trabajos/29/1/LAJOP_29_1_2_5_D131M9W9AH.pdf
Aporte de:SEDICI (UNLP) de Universidad Nacional de La Plata Ver origen
Descripción
Sumario:Rutin was isolated from dried leaves and flowers of buckwheat (Fagopyrum esculentum Moench.). The effects of rutin on angiotensin II-induced hypertrophy of cultured cardiac myocytes and proliferation of cardiac fibroblasts of neonatal rats were evaluated by analyzing the cell surface area, measuring the protein synthesis rate through 3H-leucine incorporation, and the MTT method. Rutin (0.8 to 8.0 mg/l) exhibited a strong inhibition on the hypertrophy and proliferation. The results suggested that rutin from buckwheat flowers and leaves might have protective effects on cardiac hypertrophy.