Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado

Solanaceous plants are widely distributed around the world and they are traditionally used as drugs for the treatment of cancer and herpes, and include familiar foods such as potato, tomato and eggplant and some berries popular in Brazil. As part of a program of research on pharmacologically active...

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Detalles Bibliográficos
Autores principales:	Almeida, Adelia E., Cardoso, Cássia R.P., Almeida, Daniela V., Moreira, Raquel R.D., Silva, Márcia, Varanda, Eliana A.
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2010
Materias:	Farmacia Farmacología glycoalkaloids; medicinal plants; mutagenicity; solamargine; solanum palinacanthum Plantas medicinales Efectos fisiológicos de las drogas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7880 http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_2_2.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7880
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología glycoalkaloids; medicinal plants; mutagenicity; solamargine; solanum palinacanthum Plantas medicinales Efectos fisiológicos de las drogas
spellingShingle	Farmacia Farmacología glycoalkaloids; medicinal plants; mutagenicity; solamargine; solanum palinacanthum Plantas medicinales Efectos fisiológicos de las drogas Almeida, Adelia E. Cardoso, Cássia R.P. Almeida, Daniela V. Moreira, Raquel R.D. Silva, Márcia Varanda, Eliana A. Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
topic_facet	Farmacia Farmacología glycoalkaloids; medicinal plants; mutagenicity; solamargine; solanum palinacanthum Plantas medicinales Efectos fisiológicos de las drogas
description	Solanaceous plants are widely distributed around the world and they are traditionally used as drugs for the treatment of cancer and herpes, and include familiar foods such as potato, tomato and eggplant and some berries popular in Brazil. As part of a program of research on pharmacologically active new molecules, the aim in this study was to assess the mutagenic effects of Solanum palinacanthum, known popularly as joá. The crude 95% ethanol extract and purified solamargine obtained from the fruits of S. palinacanthum Dunal were investigated by the Ames test, using the Salmonella typhimurium strains TA98, TA97a, TA100 and TA102 as test organisms, with and without metabolic activation. The concentrations tested ranged from 0.07 to 15.0 mg/plate for the crude ethanolic extract and from 1.25 to 5.0 mg/plate for the solamargine. The results showed a mutagenic effect of both the extract and the solamargine in the TA98 strain (without metabolic activation). The present study showed the potential mutagenicity and suggests confirming this effect in other models, before recommending their indiscriminate consumption by the population.
format	Articulo Comunicacion
author	Almeida, Adelia E. Cardoso, Cássia R.P. Almeida, Daniela V. Moreira, Raquel R.D. Silva, Márcia Varanda, Eliana A.
author_facet	Almeida, Adelia E. Cardoso, Cássia R.P. Almeida, Daniela V. Moreira, Raquel R.D. Silva, Márcia Varanda, Eliana A.
author_sort	Almeida, Adelia E.
title	Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
title_short	Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
title_full	Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
title_fullStr	Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
title_full_unstemmed	Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado
title_sort	mutagenicactivity of glycoallkaloids from solanum palinacanthum dunal (solanaceae) found in the brazilian cerrado
publishDate	2010
url	http://sedici.unlp.edu.ar/handle/10915/7880 http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_2_2.pdf
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Mutagenicactivity of glycoallkaloids from Solanum palinacanthum Dunal (Solanaceae) found in the brazilian cerrado

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