Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats

<i>Aloysia citriodora</i> Palau, Verbenaceae ("cedrón") is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg...

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Detalles Bibliográficos
Autores principales: Ragone, María Inés, Sella, Mariana, Pastore, Agustín, Consolini, Alicia E.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2010
Materias:
Farmacia
aloysia citriodora; cardiac inotropism; hypotensive; open-field; sedative; vitexin
Farmacología
Plantas medicinales
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7874
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_11.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7874
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
aloysia citriodora; cardiac inotropism; hypotensive; open-field; sedative; vitexin
Farmacología
Plantas medicinales
spellingShingle Farmacia
aloysia citriodora; cardiac inotropism; hypotensive; open-field; sedative; vitexin
Farmacología
Plantas medicinales
Ragone, María Inés
Sella, Mariana
Pastore, Agustín
Consolini, Alicia E.
Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
topic_facet Farmacia
aloysia citriodora; cardiac inotropism; hypotensive; open-field; sedative; vitexin
Farmacología
Plantas medicinales
description <i>Aloysia citriodora</i> Palau, Verbenaceae ("cedrón") is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg was sedative in mice on the open-field, effect which was potentiated by diazepam and sensitive to flumazenil. In normotensive rats, 1 to 30 mg AEC/kg induced a transitory hypotension, insensitive to atropine and L-NAME. Regarding an effect on α-adrenergic receptors, AEC non-competitively blocked the phenylephrine contraction on vas deferens. In isolated rat hearts, AEC induced negative inotropism, as well as vitexin, the main component. Then, the benzodiazepine-like sedation, negative inotropism and antispasmodic effect preclinically justify its popular use for abdominal cramps and as coadjuvant for anxiety and angor.
format Articulo
Articulo
author Ragone, María Inés
Sella, Mariana
Pastore, Agustín
Consolini, Alicia E.
author_facet Ragone, María Inés
Sella, Mariana
Pastore, Agustín
Consolini, Alicia E.
author_sort Ragone, María Inés
title Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
title_short Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
title_full Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
title_fullStr Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
title_full_unstemmed Sedative and cardiovascular effects of <i>Aloysia citriodora</i> Palau, on mice and rats
title_sort sedative and cardiovascular effects of <i>aloysia citriodora</i> palau, on mice and rats
publishDate 2010
url http://sedici.unlp.edu.ar/handle/10915/7874
http://www.latamjpharm.org/resumenes/29/1/LAJOP_29_1_1_11.pdf
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AT pastoreagustin sedativeandcardiovasculareffectsofialoysiacitriodoraipalauonmiceandrats
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