Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity

The aim of the present study was to investigate the role of liver in progression of insulin resistance in relation to IGF-I levels in rats with acute hepatotoxicity, induced by carbon tetrachloride (CCl4) and acetaminophen. Wistar rats were divided into four equal groups of six rats each. Group-I (s...

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Autores principales: Martha, Srinivas, Anreddy, Rama N. R., Devarakonda, Krishna R., Pantam, Narayana, Yellu, Narsimha R., Thungathurthi, Surender
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Farmacología
Insulina
Diabetes Mellitus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7854
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_2_1_F9A5E1U37S.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7854
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
Insulina
Diabetes Mellitus
spellingShingle Farmacia
Farmacología
Insulina
Diabetes Mellitus
Martha, Srinivas
Anreddy, Rama N. R.
Devarakonda, Krishna R.
Pantam, Narayana
Yellu, Narsimha R.
Thungathurthi, Surender
Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
topic_facet Farmacia
Farmacología
Insulina
Diabetes Mellitus
description The aim of the present study was to investigate the role of liver in progression of insulin resistance in relation to IGF-I levels in rats with acute hepatotoxicity, induced by carbon tetrachloride (CCl4) and acetaminophen. Wistar rats were divided into four equal groups of six rats each. Group-I (served as Control1) received olive oil, group-II received CCl4, group-III (served as control 2) received gum acacia and group-IV received acetaminophen. After 48 h of treatment, fasting blood samples were collected to determine biochemical parameters, and liver and pancreas in all groups were collected for histological evaluations. The levels of serum fasting glucose, AST, ALT, ALP, total bilirubin and insulin resistance were Significantly more in group II & IV when compared with their respective control groups. Fasting insulin and IGF-I levels in toxicant treated groups were shown significantly lower than in control groups. The liver sections of toxicant treated rats showed hydropic degeneration (ballooning) in centrilobular hepatocytes with single cell necrosis surrounded by neutrophils. The serum IGF-I level could be a useful marker for identifying subjects at risk of developing type-II diabetes mellitus and possible cardiovascular complications.
format Articulo
Comunicacion
author Martha, Srinivas
Anreddy, Rama N. R.
Devarakonda, Krishna R.
Pantam, Narayana
Yellu, Narsimha R.
Thungathurthi, Surender
author_facet Martha, Srinivas
Anreddy, Rama N. R.
Devarakonda, Krishna R.
Pantam, Narayana
Yellu, Narsimha R.
Thungathurthi, Surender
author_sort Martha, Srinivas
title Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
title_short Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
title_full Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
title_fullStr Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
title_full_unstemmed Role of liver in progression of insulin resistance in relation to IGF-I and insulin levels in rats with acute hepatotoxicity
title_sort role of liver in progression of insulin resistance in relation to igf-i and insulin levels in rats with acute hepatotoxicity
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7854
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_2_1_F9A5E1U37S.pdf
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