Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)

Ethanol extract and fractions from aerial parts of Eclipta alba (L.) Hassk (Asteraceae) were screened for the antibacterial and antifungal activities against different species of human pathogenic bacterial ATCC, antibiotic-resistant clinical isolates and strains of the dermatophyte Trichophyton rubr...

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Autores principales: Lenza, Vanessa A., Morel, Lucas J. F., Coppede, Juliana S., Fernandes, Vanessa C., Martinez-Rossi, Nilce M., França, Suzelei C., Beleboni, René O., Pereira, Paulo S., Fachin, Ana L.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Farmacología
antimicrobial activity; demethylwedelolactone; eclipta alba; wedelolactone
Extractos de plantas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7847
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_9_2DK64B9FBV.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7847
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
antimicrobial activity; demethylwedelolactone; eclipta alba; wedelolactone
Extractos de plantas
spellingShingle Farmacia
Farmacología
antimicrobial activity; demethylwedelolactone; eclipta alba; wedelolactone
Extractos de plantas
Lenza, Vanessa A.
Morel, Lucas J. F.
Coppede, Juliana S.
Fernandes, Vanessa C.
Martinez-Rossi, Nilce M.
França, Suzelei C.
Beleboni, René O.
Pereira, Paulo S.
Fachin, Ana L.
Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
topic_facet Farmacia
Farmacología
antimicrobial activity; demethylwedelolactone; eclipta alba; wedelolactone
Extractos de plantas
description Ethanol extract and fractions from aerial parts of Eclipta alba (L.) Hassk (Asteraceae) were screened for the antibacterial and antifungal activities against different species of human pathogenic bacterial ATCC, antibiotic-resistant clinical isolates and strains of the dermatophyte Trichophyton rubrum (wild and mutant for TruMDR2 gene) using a microdilution method. Demethylwedelolactone/wedelolactone (DWL/WL) and only wedelolactone (WL), both in a high homogeneity degree, were efficient to inhibit the ATCC strains of Staphylococus aureus (Minimal Inhibitory Concentration MIC = 75 μg/mL), Staphylococcus epidemidis (MIC = 125 μg/mL) and Escherichia coli (MIC = 125 μg/mL) as well as antibiotic-resistant clinical isolates of Enterococcus spp (MIC = 250 μg/mL) and S. aureus (MIC = 125 μg/mL). Ethanol extract was more effective than the purified fractions against Trichophyton rubrum strains (MIC = 125 μg/mL), suggesting that anti-fungal activity is not only related to demethylwedelolactone and wedelolactone, but also to a synergistic action between these coumestans and other compounds found in that extract. Thus, this work suggests that E. alba possesses a significant antimicrobial activity, including that against multi-drug resistant microorganisms, which could be of relevance for the treatment of infectious diseases.
format Articulo
Articulo
author Lenza, Vanessa A.
Morel, Lucas J. F.
Coppede, Juliana S.
Fernandes, Vanessa C.
Martinez-Rossi, Nilce M.
França, Suzelei C.
Beleboni, René O.
Pereira, Paulo S.
Fachin, Ana L.
author_facet Lenza, Vanessa A.
Morel, Lucas J. F.
Coppede, Juliana S.
Fernandes, Vanessa C.
Martinez-Rossi, Nilce M.
França, Suzelei C.
Beleboni, René O.
Pereira, Paulo S.
Fachin, Ana L.
author_sort Lenza, Vanessa A.
title Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
title_short Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
title_full Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
title_fullStr Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
title_full_unstemmed Antimicrobial activities of ethanol extract and coumestans from Eclipta alba (L.) Hassk (Asteraceae)
title_sort antimicrobial activities of ethanol extract and coumestans from eclipta alba (l.) hassk (asteraceae)
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7847
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_9_2DK64B9FBV.pdf
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