Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy

The aim of this study was to determine the prognostic value of expression of Excision Repair Cross-complementation Group 1 (ERCC1), B cell lymphoma/lewkmia-2 (Bcl-2) and metallothionein (MT) by immunohistochemically staining tumor specimens from 78 patients with advanced non-small-cell lung cance...

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Detalles Bibliográficos
Autores principales: Ma, Haiqing, Sun, Huanhuan, Huang, Fuxi, Li, Jing, Cao, Xiaolong, Jiang, Wenqi
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance
Quimioterapia
Farmacología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7842
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_4_1ER34O4VWY.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7842
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance
Quimioterapia
Farmacología
spellingShingle Farmacia
Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance
Quimioterapia
Farmacología
Ma, Haiqing
Sun, Huanhuan
Huang, Fuxi
Li, Jing
Cao, Xiaolong
Jiang, Wenqi
Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
topic_facet Farmacia
Bcl-2; cisplatin; ERCC1; MT; NSCL; resistance
Quimioterapia
Farmacología
description The aim of this study was to determine the prognostic value of expression of Excision Repair Cross-complementation Group 1 (ERCC1), B cell lymphoma/lewkmia-2 (Bcl-2) and metallothionein (MT) by immunohistochemically staining tumor specimens from 78 patients with advanced non-small-cell lung cancer (NSCLC) treated with cisplatin-based chemotherapy. The result showed that positive expression of ERCC1 was associated both with short survival (10.45 months vs. 14.38 months, log-rank p = 0.003) and poor response to cisplatin-based chemotherapy (p = 0.003) when compared with negative group. But expression of Bcl-2 and MT was not associated with response to chemotherapy and survival. Multivariate analysis confirmed that expression of ERCC1 was an independent variable related to overall survival (p = 0.013). These data support the role of RECC1 expression as a candidate predictor for the survival of patients with advanced NSCLC treated with cisplatin-based chemotherapy.
format Articulo
Articulo
author Ma, Haiqing
Sun, Huanhuan
Huang, Fuxi
Li, Jing
Cao, Xiaolong
Jiang, Wenqi
author_facet Ma, Haiqing
Sun, Huanhuan
Huang, Fuxi
Li, Jing
Cao, Xiaolong
Jiang, Wenqi
author_sort Ma, Haiqing
title Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
title_short Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
title_full Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
title_fullStr Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
title_full_unstemmed Expression of ERCC1, Bcl-2, MT and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
title_sort expression of ercc1, bcl-2, mt and their clinical significance in advanced non-small-cell lung cancer treated with cisplatin-based chemotherapy
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7842
http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_4_1ER34O4VWY.pdf
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bdutipo_str Repositorios
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