Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules

Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential....

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Autores principales:	Terroso, Thatiana, Külkamp, Irene C., Jornada, Denise S., Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia reología; coenzima Q10 Nanocápsulas Farmacología coenzyme Q10; rheological characterization; semi-solid formulations
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7841 http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_3_PNB636I209.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7841
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia reología; coenzima Q10 Nanocápsulas Farmacología coenzyme Q10; rheological characterization; semi-solid formulations
spellingShingle	Farmacia reología; coenzima Q10 Nanocápsulas Farmacología coenzyme Q10; rheological characterization; semi-solid formulations Terroso, Thatiana Külkamp, Irene C. Jornada, Denise S. Pohlmann, Adriana Raffin Guterres, Sílvia Stanisçuaski Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
topic_facet	Farmacia reología; coenzima Q10 Nanocápsulas Farmacología coenzyme Q10; rheological characterization; semi-solid formulations
description	Nanocapsule suspensions containing coenzyme Q10 were prepared by interfacial deposition. The nanocapsules showed characteristics compatible with dermal application: slightly acid pH, drug content close to 100%, particle size between 213 and 248 nm with low polydispersity and negative zeta potential. Three cosmetic formulations for skin application were developed, one with the free-coenzyme Q10, a second with a suspension of coenzyme Q10-loaded nanocapsules and a third containing dried coenzyme Q10-loaded nanocapsules. The dried nanocapsules were obtained by spray-drying of the suspension. No significant differences in the diameters of the particles after their incorporation in the semi-solid formulations were observed in comparison with those of nanocapsules in the aqueous suspension. The rheological characterization showed that the formulations containing coenzyme Q10-loaded nanocapsules had a pseudoplastic flow, while the formulation containing free-coenzyme Q10 had a yield-pseudoplastic flow. The semi-solid formulations containing coenzyme Q10-loaded nanocapsules suspension or powder of nanocapsules of coenzyme Q10 redispersed in water are promising cosmetic formulations for topical application.
format	Articulo Articulo
author	Terroso, Thatiana Külkamp, Irene C. Jornada, Denise S. Pohlmann, Adriana Raffin Guterres, Sílvia Stanisçuaski
author_facet	Terroso, Thatiana Külkamp, Irene C. Jornada, Denise S. Pohlmann, Adriana Raffin Guterres, Sílvia Stanisçuaski
author_sort	Terroso, Thatiana
title	Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
title_short	Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
title_full	Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
title_fullStr	Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
title_full_unstemmed	Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules
title_sort	development of semi-solid cosmetic formulations containing coenzyme q10-loaded nanocapsules
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7841 http://www.latamjpharm.org/trabajos/28/6/LAJOP_28_6_1_3_PNB636I209.pdf
work_keys_str_mv	AT terrosothatiana developmentofsemisolidcosmeticformulationscontainingcoenzymeq10loadednanocapsules AT kulkampirenec developmentofsemisolidcosmeticformulationscontainingcoenzymeq10loadednanocapsules AT jornadadenises developmentofsemisolidcosmeticformulationscontainingcoenzymeq10loadednanocapsules AT pohlmannadrianaraffin developmentofsemisolidcosmeticformulationscontainingcoenzymeq10loadednanocapsules AT guterressilviastaniscuaski developmentofsemisolidcosmeticformulationscontainingcoenzymeq10loadednanocapsules
bdutipo_str	Repositorios
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Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules

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