Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
The objective of this study was to analyze the chemical composition and evaluates further the anti-inflammatory properties of essential oil of Protium heptaphyllum resin (EOP). The essential oil was analyzed by GC/MS. Fourteen constituents, accounting for 100% of the total oil, were identified. The...
Guardado en:
| Autores principales: | , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7835 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_20_G7YDYCXVI3.pdf |
| Aporte de: |
| Sumario: | The objective of this study was to analyze the chemical composition and evaluates further the anti-inflammatory properties of essential oil of Protium heptaphyllum resin (EOP). The essential oil was analyzed by GC/MS. Fourteen constituents, accounting for 100% of the total oil, were identified. The main constituents of essential oil were limonene (49.96%), trans-β-ocimene (11.81%), eucalyptol (10.92%) and p-cymene (10.78%). EOP administered orally (100 and 200 mg/kg b.w.) significantly suppressed the development of carrageenan and egg albumin-paw edema and produced a significant inhibition of peritoneal vascular permeability induced by acetic acid. OEP also reduced peritoneal leukocytes migration, granuloma tissue formation and mast cell degranulation induced by compound 48/80 (ex-vivo). These results appear to support the potential medicine use of EOP against inflammatory conditions. |
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