Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats

The objective of this study was to analyze the chemical composition and evaluates further the anti-inflammatory properties of essential oil of Protium heptaphyllum resin (EOP). The essential oil was analyzed by GC/MS. Fourteen constituents, accounting for 100% of the total oil, were identified. The...

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Detalles Bibliográficos
Autores principales:	Amaral, Maurício P.M., Braga, Felipe A.V., Passos, Flávia F.B, Almeida, Fernanda R.C., Oliveira, Rita C.M., Carvalho, Adonias A., Chaves, Mariana H., Oliveira, Francisco
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia Farmacología actividad anti-inflamatoria; aceite esencial; limoneno; Protium heptaphyllum Plantas medicinales anti-inflammatory activity; essential oil; limonene; mast cells; Protium heptaphyllum
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7835 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_20_G7YDYCXVI3.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Farmacología actividad anti-inflamatoria; aceite esencial; limoneno; Protium heptaphyllum Plantas medicinales anti-inflammatory activity; essential oil; limonene; mast cells; Protium heptaphyllum
spellingShingle	Farmacia Farmacología actividad anti-inflamatoria; aceite esencial; limoneno; Protium heptaphyllum Plantas medicinales anti-inflammatory activity; essential oil; limonene; mast cells; Protium heptaphyllum Amaral, Maurício P.M. Braga, Felipe A.V. Passos, Flávia F.B Almeida, Fernanda R.C. Oliveira, Rita C.M. Carvalho, Adonias A. Chaves, Mariana H. Oliveira, Francisco Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
topic_facet	Farmacia Farmacología actividad anti-inflamatoria; aceite esencial; limoneno; Protium heptaphyllum Plantas medicinales anti-inflammatory activity; essential oil; limonene; mast cells; Protium heptaphyllum
description	The objective of this study was to analyze the chemical composition and evaluates further the anti-inflammatory properties of essential oil of Protium heptaphyllum resin (EOP). The essential oil was analyzed by GC/MS. Fourteen constituents, accounting for 100% of the total oil, were identified. The main constituents of essential oil were limonene (49.96%), trans-β-ocimene (11.81%), eucalyptol (10.92%) and p-cymene (10.78%). EOP administered orally (100 and 200 mg/kg b.w.) significantly suppressed the development of carrageenan and egg albumin-paw edema and produced a significant inhibition of peritoneal vascular permeability induced by acetic acid. OEP also reduced peritoneal leukocytes migration, granuloma tissue formation and mast cell degranulation induced by compound 48/80 (ex-vivo). These results appear to support the potential medicine use of EOP against inflammatory conditions.
format	Articulo Articulo
author	Amaral, Maurício P.M. Braga, Felipe A.V. Passos, Flávia F.B Almeida, Fernanda R.C. Oliveira, Rita C.M. Carvalho, Adonias A. Chaves, Mariana H. Oliveira, Francisco
author_facet	Amaral, Maurício P.M. Braga, Felipe A.V. Passos, Flávia F.B Almeida, Fernanda R.C. Oliveira, Rita C.M. Carvalho, Adonias A. Chaves, Mariana H. Oliveira, Francisco
author_sort	Amaral, Maurício P.M.
title	Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
title_short	Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
title_full	Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
title_fullStr	Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
title_full_unstemmed	Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats
title_sort	additional evidence for the anti-inflammatory properties of the essential oil of protium heptaphyllum resin in mice and rats
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7835 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_20_G7YDYCXVI3.pdf
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Additional evidence for the anti-inflammatory properties of the essential oil of Protium heptaphyllum resin in mice and rats

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