Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study

The present study aims at developing synthesized (PVA-co-PAA)/NaCl normal hydrogel(H), hydrogel microspheres(HM) and comparing the antihypertensive activity of Diltiazem hydrochloride(DL) from two formulations. The hydrogel microspheres were crosslinked by using glutaraldehyde-saturated toluene. The...

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Autores principales: Ray, Debajyoti, Mohanta, Guru P., Gils, P. Sunny, Manavalan, R., Sahoo, Prafulla K.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Farmacología
drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling
Medicamentos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7831
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_16_M7IJPD4ANB.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7831
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling
Medicamentos
spellingShingle Farmacia
Farmacología
drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling
Medicamentos
Ray, Debajyoti
Mohanta, Guru P.
Gils, P. Sunny
Manavalan, R.
Sahoo, Prafulla K.
Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
topic_facet Farmacia
Farmacología
drug delivery; hydrogel microspheres; normal hydrogel; stability; swelling
Medicamentos
description The present study aims at developing synthesized (PVA-co-PAA)/NaCl normal hydrogel(H), hydrogel microspheres(HM) and comparing the antihypertensive activity of Diltiazem hydrochloride(DL) from two formulations. The hydrogel microspheres were crosslinked by using glutaraldehyde-saturated toluene. The hydrogel showed more swelling in simulated intestinal fluid (SIF). (PVA-co-PAA)/NaCl HM formulation A1 showed comparatively higher entrapment (79%) and better control over DL release. In normotensive rats, HM formulation A1 found more effectively in reducing blood pressure to 40.1%. The experimental results demonstrated that (PVA-co-PAA)/NaCl HM had the greater potential than normal hydrogel to be used as a drug carrier.
format Articulo
Articulo
author Ray, Debajyoti
Mohanta, Guru P.
Gils, P. Sunny
Manavalan, R.
Sahoo, Prafulla K.
author_facet Ray, Debajyoti
Mohanta, Guru P.
Gils, P. Sunny
Manavalan, R.
Sahoo, Prafulla K.
author_sort Ray, Debajyoti
title Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
title_short Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
title_full Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
title_fullStr Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
title_full_unstemmed Delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
title_sort delivery of antihypertensive drug through synthesized hydrogel network, a comparative study
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7831
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_16_M7IJPD4ANB.pdf
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AT manavalanr deliveryofantihypertensivedrugthroughsynthesizedhydrogelnetworkacomparativestudy
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