Adsorptive voltammetric determination of nimesulide at glassy carbon electrode
A voltammetric method is described for the determination of nimesulide based on the reduction of the nitro group at glassy carbon electrode. The voltammetric behavior of the drug was investigated in Britton-Robinson buffer (pH 2.0-12.0) applying cyclic voltammetry technique. One cathodic and one ano...
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| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7830 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_15_A8974OWUBP.pdf |
| Aporte de: |
| id |
I19-R120-10915-7830 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Farmacología cyclic voltammetry; glassy carbon electrode; linear sweep; nimesulide; serum |
| spellingShingle |
Farmacia Farmacología cyclic voltammetry; glassy carbon electrode; linear sweep; nimesulide; serum Sayed, Gamal O. el- Yasin, Shalaby A. Ries, Mohammed A. el- Badawy, Azza A. el- Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| topic_facet |
Farmacia Farmacología cyclic voltammetry; glassy carbon electrode; linear sweep; nimesulide; serum |
| description |
A voltammetric method is described for the determination of nimesulide based on the reduction of the nitro group at glassy carbon electrode. The voltammetric behavior of the drug was investigated in Britton-Robinson buffer (pH 2.0-12.0) applying cyclic voltammetry technique. One cathodic and one anodic peaks were observed. The comparison of peak heights and potentials indicated that these peaks are quasi-reversible. The determination of nimesulide in pure form was performed using adsorptive linear sweep voltammetry. The cathodic peak current varied linearly in the range 4.0x10<sup>-7</sup> - 5.0x10<sup>-5</sup> M (0.116 - 14.65 μg mL<sup>-1</sup> ). The limits of detection (LOD) and quantification (LOQ) were 3.2x10<sup>-8</sup> and 1.06x10<sup>-7</sup> mol L<sup>-1</sup> , respectively. The proposed method was applied to pharmaceutical formulations with percent recoveries in the range 98.00-101.60%, and a relative standard deviation of 0.61-1.46%. The validity of the method was performed to the determination of nimesulide in human serum with acceptable results for biological samples. No sample pre-treatments or solvent extraction procedures were needed. |
| format |
Articulo Articulo |
| author |
Sayed, Gamal O. el- Yasin, Shalaby A. Ries, Mohammed A. el- Badawy, Azza A. el- |
| author_facet |
Sayed, Gamal O. el- Yasin, Shalaby A. Ries, Mohammed A. el- Badawy, Azza A. el- |
| author_sort |
Sayed, Gamal O. el- |
| title |
Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| title_short |
Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| title_full |
Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| title_fullStr |
Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| title_full_unstemmed |
Adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| title_sort |
adsorptive voltammetric determination of nimesulide at glassy carbon electrode |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7830 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_15_A8974OWUBP.pdf |
| work_keys_str_mv |
AT sayedgamaloel adsorptivevoltammetricdeterminationofnimesulideatglassycarbonelectrode AT yasinshalabya adsorptivevoltammetricdeterminationofnimesulideatglassycarbonelectrode AT riesmohammedael adsorptivevoltammetricdeterminationofnimesulideatglassycarbonelectrode AT badawyazzaael adsorptivevoltammetricdeterminationofnimesulideatglassycarbonelectrode |
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Repositorios |
| _version_ |
1764820485711855616 |