Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats

D-003 is a mixture of higher fatty acids purified from sugarcane wax with antiosteoporotic effects in ovariectomized (ovx) rats. Omega-3 fatty acids (Ω-3FA) have shown bone-protective effects. This study compared the effect of D-003 and Ω-3 FA on bones of ovx rats. Rats were randomized into 4 groups...

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Autores principales:	Noa, Miriam, Más, Rosa, Mendoza, Sarahí, Valle, Maikel, Mendoza, Nilda, Goicochea, Eddy
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia histomorfometría; osteoporosis; huesos; Omega-3 Farmacología bones; D-003; histomorphometry; Omega-3 fatty acids; osteoporosis; ovariectomized rats
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7828 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_13_V6F1B3M8D0.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia histomorfometría; osteoporosis; huesos; Omega-3 Farmacología bones; D-003; histomorphometry; Omega-3 fatty acids; osteoporosis; ovariectomized rats
spellingShingle	Farmacia histomorfometría; osteoporosis; huesos; Omega-3 Farmacología bones; D-003; histomorphometry; Omega-3 fatty acids; osteoporosis; ovariectomized rats Noa, Miriam Más, Rosa Mendoza, Sarahí Valle, Maikel Mendoza, Nilda Goicochea, Eddy Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
topic_facet	Farmacia histomorfometría; osteoporosis; huesos; Omega-3 Farmacología bones; D-003; histomorphometry; Omega-3 fatty acids; osteoporosis; ovariectomized rats
description	D-003 is a mixture of higher fatty acids purified from sugarcane wax with antiosteoporotic effects in ovariectomized (ovx) rats. Omega-3 fatty acids (Ω-3FA) have shown bone-protective effects. This study compared the effect of D-003 and Ω-3 FA on bones of ovx rats. Rats were randomized into 4 groups: one false-operated and three ovx groups: a positive control treated orally with the vehicle, one with D-003 (50 mg/kg) and other with Ω-3FA (160 mg/kg) for 3 months. Ovariectomy decreased trabecular volume, number and thickness in the fifth vertebrae, distal femur and femur neck, and increased trabecular separation, osteoclast number and surface versus the false-operated group. D-003 and Ω-3 FA prevented all changes induced by ovariectomy, but the effects of D-003 were significantly greater than those of Ω-3FA. Concluding, D-003 (50 mg/kg) and Ω-3FA (160 mg/kg) prevented osteoporotic changes in ovx rats, but D- 003 was more effective than the Ω-3FA preparation assayed.
format	Articulo Articulo
author	Noa, Miriam Más, Rosa Mendoza, Sarahí Valle, Maikel Mendoza, Nilda Goicochea, Eddy
author_facet	Noa, Miriam Más, Rosa Mendoza, Sarahí Valle, Maikel Mendoza, Nilda Goicochea, Eddy
author_sort	Noa, Miriam
title	Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
title_short	Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
title_full	Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
title_fullStr	Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
title_full_unstemmed	Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats
title_sort	effects of d-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and omega-3 fatty acids on bones of ovariectomized rats
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7828 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_13_V6F1B3M8D0.pdf
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Effects Of D-003, a mixture of high-molecular weight aliphatic acids from sugarcane wax, and Omega-3 fatty acids on bones of ovariectomized rats

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