Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules

Sibutramine hydrochloride monohydrate (SHM) has been widely used for the management of overweight and obesity. However, more restrict data have been regarded about in vitro dissolution profile of SHM from pharmaceutical dosage forms. The goal of this paper was to perform a comparative analysis on di...

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Detalles Bibliográficos
Autores principales: Maluf, Daniela F., Farago, Paulo V., Barreira, Sandra M. W., Pontarolo, Roberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Farmacología
capsules; comparative analysis; dissolution profile; sibutramine hydrochloride monohydrate
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7827
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_12_B39H417273.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7827
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Farmacología
capsules; comparative analysis; dissolution profile; sibutramine hydrochloride monohydrate
spellingShingle Farmacia
Farmacología
capsules; comparative analysis; dissolution profile; sibutramine hydrochloride monohydrate
Maluf, Daniela F.
Farago, Paulo V.
Barreira, Sandra M. W.
Pontarolo, Roberto
Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
topic_facet Farmacia
Farmacología
capsules; comparative analysis; dissolution profile; sibutramine hydrochloride monohydrate
description Sibutramine hydrochloride monohydrate (SHM) has been widely used for the management of overweight and obesity. However, more restrict data have been regarded about in vitro dissolution profile of SHM from pharmaceutical dosage forms. The goal of this paper was to perform a comparative analysis on dissolution profiles of SHM from four commercial capsules (formulations F1, F2, F3 and F4) available in the Brazilian pharmaceutical market. All studied preparations reached a plateau from 85 to 100% of dissolution within 20 min in purified water, HCl 0.1 mol L<sup>-1</sup> (pH 1.2) and phosphate buffer solution (PBS pH 6.8) that can be reported as an immediate release behavior. Formulation F4 showed the lower dissolution efficiency (73.40%) in PBS medium. However, since similarity/difference data and analysis of variance were carried out, results demonstrated no statistical differences among the evaluated formulations in the three used media. Weibull equation was chosen as the most suitable kinetic model that better adjusted the experimental dissolution data.
format Articulo
Articulo
author Maluf, Daniela F.
Farago, Paulo V.
Barreira, Sandra M. W.
Pontarolo, Roberto
author_facet Maluf, Daniela F.
Farago, Paulo V.
Barreira, Sandra M. W.
Pontarolo, Roberto
author_sort Maluf, Daniela F.
title Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
title_short Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
title_full Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
title_fullStr Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
title_full_unstemmed Comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
title_sort comparative study on dissolution profiles of sibutramine hydrochloride monohydrate from commercial capsules
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7827
http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_12_B39H417273.pdf
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AT barreirasandramw comparativestudyondissolutionprofilesofsibutraminehydrochloridemonohydratefromcommercialcapsules
AT pontaroloroberto comparativestudyondissolutionprofilesofsibutraminehydrochloridemonohydratefromcommercialcapsules
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