Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies

The present investigation aims at feasibility assessment of ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) based ondansetron hydrochloride matrix type transdermal systems. The effects of polymeric concentration, its blend and drug loading dose on the in vitro drug permeation from the transderma...

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Autores principales:	Swain, Kalpana, Pattnaik, Satyanarayan, Sahu, Sarat Chandra, Mallick, Subrata
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia ondansetron hydrochloride; permeation; SEM; transdermal delivery; XRD Farmacología
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7825 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_10_14OTK55UFH.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7825
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia ondansetron hydrochloride; permeation; SEM; transdermal delivery; XRD Farmacología
spellingShingle	Farmacia ondansetron hydrochloride; permeation; SEM; transdermal delivery; XRD Farmacología Swain, Kalpana Pattnaik, Satyanarayan Sahu, Sarat Chandra Mallick, Subrata Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
topic_facet	Farmacia ondansetron hydrochloride; permeation; SEM; transdermal delivery; XRD Farmacología
description	The present investigation aims at feasibility assessment of ethyl cellulose (EC) and polyvinylpyrrolidone (PVP) based ondansetron hydrochloride matrix type transdermal systems. The effects of polymeric concentration, its blend and drug loading dose on the in vitro drug permeation from the transdermal patches has been investigated. Ratio of EC: PVP and drug loading dose were selected as independent variables and their influence on the amount drug permeated at 24 h, permeation flux and steady state permeability coefficient were studied using experimental design. Various physicochemical parameters were studied to assess the feasibility of the transdermal systems. Ratio of EC: PVP was found to be the main influential factor for all the dependent variables studied. Drug loading dose was also found to influence the dependent variables but to a lesser extent. Physicochemical parameters of the prepared patches were evaluated and found satisfactory. Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction studies confirmed amorphous state of ondansetron in the transdermal system. The study indicated the need for permeation enhancement techniques to meet the clinical requirement.
format	Articulo Articulo
author	Swain, Kalpana Pattnaik, Satyanarayan Sahu, Sarat Chandra Mallick, Subrata
author_facet	Swain, Kalpana Pattnaik, Satyanarayan Sahu, Sarat Chandra Mallick, Subrata
author_sort	Swain, Kalpana
title	Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
title_short	Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
title_full	Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
title_fullStr	Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
title_full_unstemmed	Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies
title_sort	feasibility assessment of ondansetron hydrochloride transdermal systems: physicochemical characterization and in vitro permeation studies
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7825 http://www.latamjpharm.org/trabajos/28/5/LAJOP_28_5_1_10_14OTK55UFH.pdf
work_keys_str_mv	AT swainkalpana feasibilityassessmentofondansetronhydrochloridetransdermalsystemsphysicochemicalcharacterizationandinvitropermeationstudies AT pattnaiksatyanarayan feasibilityassessmentofondansetronhydrochloridetransdermalsystemsphysicochemicalcharacterizationandinvitropermeationstudies AT sahusaratchandra feasibilityassessmentofondansetronhydrochloridetransdermalsystemsphysicochemicalcharacterizationandinvitropermeationstudies AT mallicksubrata feasibilityassessmentofondansetronhydrochloridetransdermalsystemsphysicochemicalcharacterizationandinvitropermeationstudies
bdutipo_str	Repositorios
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Feasibility assessment of ondansetron hydrochloride transdermal systems: Physicochemical characterization and In vitro permeation studies

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