Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug

The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class-II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil an...

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Detalles Bibliográficos
Autores principales: Kamila, Madan M., Mondal, Nita, Gupta, Bijan Kumar, Ghosh, Lakshmi K.
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
celecoxib; dynamic light scattering; microemulsion; phase behavior; Tween 80
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7813
http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_10_SOB39M454H.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7813
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
celecoxib; dynamic light scattering; microemulsion; phase behavior; Tween 80
spellingShingle Farmacia
celecoxib; dynamic light scattering; microemulsion; phase behavior; Tween 80
Kamila, Madan M.
Mondal, Nita
Gupta, Bijan Kumar
Ghosh, Lakshmi K.
Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
topic_facet Farmacia
celecoxib; dynamic light scattering; microemulsion; phase behavior; Tween 80
description The aim of the present study was to prepare, characterize and in-vitro evaluation of a Winsor-IV type microemulsion based drug delivery system incorporating celecoxib as BCS class-II model drug. Attempts were made to prepare cost effective O/W microemulsion using Tween 80, Glycerol, sunflower oil and water. The existence of microemulsion zone was investigated using phase diagrams. The systems were characterized by polarized light microscopy, viscosity, refractive index, droplet size of dispersed phase by dynamic light scattering technique, thermal and centrifugal stability and the drug release profile. The obtained microemulsion was found optically isotropic with non-Newtonian behavior. The average droplet size was 100-300 nm. Microemulsions showed reversibility of transparency at ambient temperature after storage at 5 °C. The solubility enhancement of formulated products was apparent from higher release rate from microemulsion as compared to commercial product. The drug release profile was demonstrated to be promising for oral delivery of celecoxib.
format Articulo
Comunicacion
author Kamila, Madan M.
Mondal, Nita
Gupta, Bijan Kumar
Ghosh, Lakshmi K.
author_facet Kamila, Madan M.
Mondal, Nita
Gupta, Bijan Kumar
Ghosh, Lakshmi K.
author_sort Kamila, Madan M.
title Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
title_short Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
title_full Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
title_fullStr Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
title_full_unstemmed Preparation, characterization and in-vitro evaluation of sunflower oil-Tween 80-Glycerol-based microemulsion formulation of a BCS class-II Drug
title_sort preparation, characterization and in-vitro evaluation of sunflower oil-tween 80-glycerol-based microemulsion formulation of a bcs class-ii drug
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7813
http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_10_SOB39M454H.pdf
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