Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice

The aim of this work is to evaluate in vivo the anti-inflammatory effect of creams containing kaurenoic acid (KA), isolated from the acetonic extract of the W. paludosa (stems and roots). The herbal drug was incorporated into anionic cream (Lanette®) at 100 μg/g. Creams containing different permeati...

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Detalles Bibliográficos
Autores principales: Carli, Roseni B.G. de, Siqueira, Paula R.A., Kaiser, Marina L., Freitas, Rilton A., Souza, Márcia María de, Cechinel Filho, Valdir, Lucinda da Silva, Ruth Meri
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
kaurenoic acid; phytodrug; Wedelia paludosa
Medicamentos
Agentes Antiinflamatorios
Extractos de plantas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7807
http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_4_8CC284YK9Z.pdf
Aporte de:
Aportado por : SEDICI (UNLP) de Universidad Nacional de La Plata .
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spelling I19-R120-10915-78072013-10-17T12:02:29Z http://sedici.unlp.edu.ar/handle/10915/7807 http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_4_8CC284YK9Z.pdf Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice Carli, Roseni B.G. de Siqueira, Paula R.A. Kaiser, Marina L. Freitas, Rilton A. Souza, Márcia María de Cechinel Filho, Valdir Lucinda da Silva, Ruth Meri 2009 2009-09-30T03:00:00Z en Farmacia kaurenoic acid; phytodrug; Wedelia paludosa Medicamentos Agentes Antiinflamatorios Extractos de plantas The aim of this work is to evaluate in vivo the anti-inflammatory effect of creams containing kaurenoic acid (KA), isolated from the acetonic extract of the W. paludosa (stems and roots). The herbal drug was incorporated into anionic cream (Lanette®) at 100 μg/g. Creams containing different permeation enhancers (urea, alpha bisabolol, isodecyl oleate, isopropyl myristate, soy lecithin) were prepared, and the in vivo topical anti-inflammatory effect was evaluated by the croton oil-induced ear edema method in mice using dexamethasone cream (5 mg/g) and Acheflan® (essential oil of Cordia verbenacea 5 mg/g) as positive control. The potential cutaneous irritation was evaluated by the agarose overlay assay. KA cream, KA and isopropyl myristate and soy lecithin cream and dexamethasone cream presented inhibition of ear edema of 61.73 ± 23.23%, 71.71 ± 15.77% and 64.45 ± 13.41%, respectively. These results suggest that KA incorporated in the cream showed a greater anti-inflammatory effect than positive control, while KA cream containing a concentration lower than dexamethasone cream presents a statistically similar ear edema reduction compared with the control, with no potential cutaneous irritation being observed. Colegio de Farmacéuticos de la Provincia de Buenos Aires Articulo Comunicacion 594-598
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
kaurenoic acid; phytodrug; Wedelia paludosa
Medicamentos
Agentes Antiinflamatorios
Extractos de plantas
spellingShingle Farmacia
kaurenoic acid; phytodrug; Wedelia paludosa
Medicamentos
Agentes Antiinflamatorios
Extractos de plantas
Carli, Roseni B.G. de
Siqueira, Paula R.A.
Kaiser, Marina L.
Freitas, Rilton A.
Souza, Márcia María de
Cechinel Filho, Valdir
Lucinda da Silva, Ruth Meri
Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
topic_facet Farmacia
kaurenoic acid; phytodrug; Wedelia paludosa
Medicamentos
Agentes Antiinflamatorios
Extractos de plantas
description The aim of this work is to evaluate in vivo the anti-inflammatory effect of creams containing kaurenoic acid (KA), isolated from the acetonic extract of the W. paludosa (stems and roots). The herbal drug was incorporated into anionic cream (Lanette®) at 100 μg/g. Creams containing different permeation enhancers (urea, alpha bisabolol, isodecyl oleate, isopropyl myristate, soy lecithin) were prepared, and the in vivo topical anti-inflammatory effect was evaluated by the croton oil-induced ear edema method in mice using dexamethasone cream (5 mg/g) and Acheflan® (essential oil of Cordia verbenacea 5 mg/g) as positive control. The potential cutaneous irritation was evaluated by the agarose overlay assay. KA cream, KA and isopropyl myristate and soy lecithin cream and dexamethasone cream presented inhibition of ear edema of 61.73 ± 23.23%, 71.71 ± 15.77% and 64.45 ± 13.41%, respectively. These results suggest that KA incorporated in the cream showed a greater anti-inflammatory effect than positive control, while KA cream containing a concentration lower than dexamethasone cream presents a statistically similar ear edema reduction compared with the control, with no potential cutaneous irritation being observed.
format Articulo
Comunicacion
author Carli, Roseni B.G. de
Siqueira, Paula R.A.
Kaiser, Marina L.
Freitas, Rilton A.
Souza, Márcia María de
Cechinel Filho, Valdir
Lucinda da Silva, Ruth Meri
author_facet Carli, Roseni B.G. de
Siqueira, Paula R.A.
Kaiser, Marina L.
Freitas, Rilton A.
Souza, Márcia María de
Cechinel Filho, Valdir
Lucinda da Silva, Ruth Meri
author_sort Carli, Roseni B.G. de
title Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
title_short Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
title_full Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
title_fullStr Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
title_full_unstemmed Topical anti-inflammatory effect of creams containing kaurenoic acid isolated from Wedelia paludosa in Mice
title_sort topical anti-inflammatory effect of creams containing kaurenoic acid isolated from wedelia paludosa in mice
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7807
http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_2_4_8CC284YK9Z.pdf
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