Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods
The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile c...
Guardado en:
| Autores principales: | , , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7798 http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_1_10_292K1ZU8TN.pdf |
| Aporte de: |
| id |
I19-R120-10915-7798 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia ANOVA; dissolution; fenofibrate; liquisolid tablets |
| spellingShingle |
Farmacia ANOVA; dissolution; fenofibrate; liquisolid tablets Karmarkar, Amrit B. Gonjari, Indrajeet D. Dhabale, Pandurang N. Bhise, Satish B. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| topic_facet |
Farmacia ANOVA; dissolution; fenofibrate; liquisolid tablets |
| description |
The present work deals with the comparison of in vitro dissolution profiles of fenofibrate liquisolid tablet formulations with those of marketed fenofibrate tablets, and the application of statistical methods to evaluate each method for its usefulness. The methods used to study dissolution profile comparison include Model independent method (Similarity factor, f2); Model dependent methods (Zero order, First order, Hixson-Crowell, Matrix, Peppas, Higuchi models) and statistical methods based on ANOVA. Model independent method was found to be easier and simple to interpret. The f2 value relates closeness of dissolution profiles. Dissolution profile followed Peppas model as "best fit" model. The application and evaluation of model dependent methods are more complicated. These methods give acceptable model approach which is indication of true relationship between percent drug release and time variables, including statistical assumptions. Statistical approach is very simple and is more discriminative of dissolution profiles. The liquisolid formulation of fenofibrate serves to be an effective way to enhance dissolution rate of fenofibrate |
| format |
Articulo Articulo |
| author |
Karmarkar, Amrit B. Gonjari, Indrajeet D. Dhabale, Pandurang N. Bhise, Satish B. |
| author_facet |
Karmarkar, Amrit B. Gonjari, Indrajeet D. Dhabale, Pandurang N. Bhise, Satish B. |
| author_sort |
Karmarkar, Amrit B. |
| title |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| title_short |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| title_full |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| title_fullStr |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| title_full_unstemmed |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique : Part II: evaluation of in vitro dissolution profile comparison methods |
| title_sort |
dissolution rate enhancement of fenofibrate using liquisolid tablet technique : part ii: evaluation of in vitro dissolution profile comparison methods |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7798 http://www.latamjpharm.org/trabajos/28/4/LAJOP_28_4_1_10_292K1ZU8TN.pdf |
| work_keys_str_mv |
AT karmarkaramritb dissolutionrateenhancementoffenofibrateusingliquisolidtablettechniquepartiievaluationofinvitrodissolutionprofilecomparisonmethods AT gonjariindrajeetd dissolutionrateenhancementoffenofibrateusingliquisolidtablettechniquepartiievaluationofinvitrodissolutionprofilecomparisonmethods AT dhabalepandurangn dissolutionrateenhancementoffenofibrateusingliquisolidtablettechniquepartiievaluationofinvitrodissolutionprofilecomparisonmethods AT bhisesatishb dissolutionrateenhancementoffenofibrateusingliquisolidtablettechniquepartiievaluationofinvitrodissolutionprofilecomparisonmethods |
| bdutipo_str |
Repositorios |
| _version_ |
1764820485272502272 |