Antinociceptive activity of Malva sylvestris L.
The antinociceptive activity of Malva sylvestris (Malvaceae) aqueous extract (10 mg/kg, i.p.) was evaluated against classical models of pain in mice, indicating promising results. It showed significant antinociceptive activity in writhing test (76.4% of inhibition) and also inhibited the neurogenic...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7783 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_2_1_2GIHF4DUOF.pdf |
| Aporte de: |
| id |
I19-R120-10915-7783 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia antinociception; aqueous extract; capsaicin test; formalin test; Malva sylvestris L.; whrithing test |
| spellingShingle |
Farmacia antinociception; aqueous extract; capsaicin test; formalin test; Malva sylvestris L.; whrithing test Esteves, Patricia Fontes Sato, Alice Esquibel, María Aparecida Campos-Buzzi, Fátima de Meira, Aleandra V. Antinociceptive activity of Malva sylvestris L. |
| topic_facet |
Farmacia antinociception; aqueous extract; capsaicin test; formalin test; Malva sylvestris L.; whrithing test |
| description |
The antinociceptive activity of Malva sylvestris (Malvaceae) aqueous extract (10 mg/kg, i.p.) was evaluated against classical models of pain in mice, indicating promising results. It showed significant antinociceptive activity in writhing test (76.4% of inhibition) and also inhibited the neurogenic (61.8%)
and inflammatory (46.6%) phases of the formalin model. When analysed against capsaicin-induced pain model, the aqueous extract was also effective with inhibition of 62.9%, but it did not cause significant activity against hot-plate model. The results suggest that the antinociception caused by aqueous extract is related to the inhibition of prostaglandins synthesis pathway cyclooxygenase and unrelated to the stimulation
of the opioid receptors. |
| format |
Articulo Comunicacion |
| author |
Esteves, Patricia Fontes Sato, Alice Esquibel, María Aparecida Campos-Buzzi, Fátima de Meira, Aleandra V. |
| author_facet |
Esteves, Patricia Fontes Sato, Alice Esquibel, María Aparecida Campos-Buzzi, Fátima de Meira, Aleandra V. |
| author_sort |
Esteves, Patricia Fontes |
| title |
Antinociceptive activity of Malva sylvestris L. |
| title_short |
Antinociceptive activity of Malva sylvestris L. |
| title_full |
Antinociceptive activity of Malva sylvestris L. |
| title_fullStr |
Antinociceptive activity of Malva sylvestris L. |
| title_full_unstemmed |
Antinociceptive activity of Malva sylvestris L. |
| title_sort |
antinociceptive activity of malva sylvestris l. |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7783 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_2_1_2GIHF4DUOF.pdf |
| work_keys_str_mv |
AT estevespatriciafontes antinociceptiveactivityofmalvasylvestrisl AT satoalice antinociceptiveactivityofmalvasylvestrisl AT esquibelmariaaparecida antinociceptiveactivityofmalvasylvestrisl AT camposbuzzifatimade antinociceptiveactivityofmalvasylvestrisl AT meiraaleandrav antinociceptiveactivityofmalvasylvestrisl |
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Repositorios |
| _version_ |
1764820485120458752 |