Antiviral activity of carrageenans from marine red algae

Three carrageenan representatives of each structural type: λ- and ι –family (Gigartina acicularis), ι-family (Euchema denticulatum) and κ –family (Kappaphycus cottonii) have been tested for their in vitro antiviral activity. The carrageenans proved to be potent inhibitors of herpes human virus type...

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Autores principales:	Montanha, Jarbas, Bourgougnon, Nathalie, Boustie, Joel, Amoros, Maryvonne
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7781 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_18_Q6BLEVWVR0.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7781
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae
spellingShingle	Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne Antiviral activity of carrageenans from marine red algae
topic_facet	Farmacia antivirales; carragenanos; herpes simple; poliovirus; polisacáridos; algas rojas antiviral; carrageenan; herpes simplex viruses; poliovirus; polysaccharide; red algae
description	Three carrageenan representatives of each structural type: λ- and ι –family (Gigartina acicularis), ι-family (Euchema denticulatum) and κ –family (Kappaphycus cottonii) have been tested for their in vitro antiviral activity. The carrageenans proved to be potent inhibitors of herpes human virus type 1 (HHV-1) and Poliovirus. The best results were obtained with carrageenans from Gigartina acicularis and Euchema denticulatum, which are more sulfated than those from Kappaphycus cottonii. The selective index values (CC50 /ID50 ) ranged from more than 22 to more than 545 for HHV-1 and more than 6.6 to more than 32 for Poliovirus. No citotoxic effects were observed. At 0.75 mg/ml, none of the carrageenans tested showed a virucidal activity against HHV-1 or Poliovirus. Carrageenans from Euchema denticulatum (ι- family) and Gigartina acicularis (λ- and ι –family) exerted their antiviral effect via, in part, by a lower inhibition of the virus attachment and by the interference in a subsequent stage of the virus replicative cycle. The κ-carrageenan from Kappaphycus cottonii exerted its antiviral effect mainly by a lower inhibition of the virus attachment. In cultures treated with carrageenans from Euchema denticulatum (ι-family) and Gigartina acicularis (λ- and ι –family), the HHV-1 viral DNA synthesis had a reduction of threefold and twofold with 0.75 mg/ml, respectively.
format	Articulo Articulo
author	Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne
author_facet	Montanha, Jarbas Bourgougnon, Nathalie Boustie, Joel Amoros, Maryvonne
author_sort	Montanha, Jarbas
title	Antiviral activity of carrageenans from marine red algae
title_short	Antiviral activity of carrageenans from marine red algae
title_full	Antiviral activity of carrageenans from marine red algae
title_fullStr	Antiviral activity of carrageenans from marine red algae
title_full_unstemmed	Antiviral activity of carrageenans from marine red algae
title_sort	antiviral activity of carrageenans from marine red algae
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7781 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_18_Q6BLEVWVR0.pdf
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bdutipo_str	Repositorios
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Antiviral activity of carrageenans from marine red algae

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