Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin

The purpose of the present investigation was to evaluate 6-O-palmitoyl ascorbic acid (ASC16) and 6-O-lauril ascorbic acid (ASC12) for their capacity to promote permeation of Ibuprofen (IBU) through hairless mouse skin in vitro. The permeation of Arfen® (IBU 10% P/P, commercial product), IBU solution...

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Detalles Bibliográficos
Autores principales:	Saino, Verónica, Chetoni, Patrizia, Palma, Santiago D., Allemandi, Daniel A.
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia ibuprofen; lquid crystals; skin permeation Medicamento Farmacología Agentes Antiinflamatorios Evaluación de drogas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7780 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_17_9C8955F2PI.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7780
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia ibuprofen; lquid crystals; skin permeation Medicamento Farmacología Agentes Antiinflamatorios Evaluación de drogas
spellingShingle	Farmacia ibuprofen; lquid crystals; skin permeation Medicamento Farmacología Agentes Antiinflamatorios Evaluación de drogas Saino, Verónica Chetoni, Patrizia Palma, Santiago D. Allemandi, Daniel A. Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
topic_facet	Farmacia ibuprofen; lquid crystals; skin permeation Medicamento Farmacología Agentes Antiinflamatorios Evaluación de drogas
description	The purpose of the present investigation was to evaluate 6-O-palmitoyl ascorbic acid (ASC16) and 6-O-lauril ascorbic acid (ASC12) for their capacity to promote permeation of Ibuprofen (IBU) through hairless mouse skin in vitro. The permeation of Arfen® (IBU 10% P/P, commercial product), IBU solution (0.85% P/P, pH 7.4, 66.7 mM phosphate buffer: Isopropyl alcohol; 80:20) and IBU (0.85% P/P) vehiculized in ASCn coagels (5% w/v) were measured and comparatively analyzed. Although IBU release from the formulation was faster in the case of Arfen® in comparison to ASCn coagel, the permeation of IBU was significantly increased when the drug was vehiculized in these systems, being ASC12 the most effective as enhancer. This result demonstrated the potential usefulness of the lamellar liquid crystalline system obtained from ASCn auto-aggregation for topical administration of drugs.
format	Articulo Articulo
author	Saino, Verónica Chetoni, Patrizia Palma, Santiago D. Allemandi, Daniel A.
author_facet	Saino, Verónica Chetoni, Patrizia Palma, Santiago D. Allemandi, Daniel A.
author_sort	Saino, Verónica
title	Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
title_short	Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
title_full	Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
title_fullStr	Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
title_full_unstemmed	Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin
title_sort	effect of different coagels of 6-o-ascorbic acid alkanoates on permeation of ibuprofen through hairless mouse skin
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7780 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_17_9C8955F2PI.pdf
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bdutipo_str	Repositorios
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Effect of different coagels of 6-O-ascorbic acid alkanoates on permeation of Ibuprofen through hairless mouse skin

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