Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

W/O/W multiple emulsions containing naltrexone (NTX) hydrochloride were prepared by a two-step emulsification method at 20 ºC. Characterization of the developed system was evaluated and the release kinetics of the drug was determined. The tissue response to the injection of the multiple emulsion in...

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Detalles Bibliográficos
Autores principales:	Oliveira, Bérgson F., Ferreira, Ana E.R., Fialho, Sílvia L., Silva Cunha Júnior, Armando da
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia alcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion Alcoholismo Evaluación de drogas Productos químicos y drogas
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7776 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_12_HFO4TCESP6.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7776
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia alcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion Alcoholismo Evaluación de drogas Productos químicos y drogas
spellingShingle	Farmacia alcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion Alcoholismo Evaluación de drogas Productos químicos y drogas Oliveira, Bérgson F. Ferreira, Ana E.R. Fialho, Sílvia L. Silva Cunha Júnior, Armando da Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
topic_facet	Farmacia alcohol dependence; drug delivery system; naltrexone hydrochloride; W/O/W multiple emulsion Alcoholismo Evaluación de drogas Productos químicos y drogas
description	W/O/W multiple emulsions containing naltrexone (NTX) hydrochloride were prepared by a two-step emulsification method at 20 ºC. Characterization of the developed system was evaluated and the release kinetics of the drug was determined. The tissue response to the injection of the multiple emulsion in mice was observed by histological analysis. The entrapment efficiency of NTX hydrochloride in W/O/W multiple emulsion was 97.72 ± 0.8 % and the mean diameter of the multiple globules was 18.6 ± 7.7 μm. The main in vitro drug release mechanism observed for the developed system is supposed to be a swellingbreakdown phenomenon after dilution of the emulsions under hypo-osmotic conditions. Biocompatibility studies showed that the multiple emulsion was well tolerated as no significant toxic reaction was observed. The W/O/W multiple emulsion containing NTX hydrochloride may represent a potential alternative dosage form for the treatment of alcohol dependence.
format	Articulo Articulo
author	Oliveira, Bérgson F. Ferreira, Ana E.R. Fialho, Sílvia L. Silva Cunha Júnior, Armando da
author_facet	Oliveira, Bérgson F. Ferreira, Ana E.R. Fialho, Sílvia L. Silva Cunha Júnior, Armando da
author_sort	Oliveira, Bérgson F.
title	Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
title_short	Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
title_full	Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
title_fullStr	Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
title_full_unstemmed	Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study
title_sort	preparation and evaluation of w/o/w multiple emulsion containing naltrexone hydrochloride: a pilot study
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7776 http://www.latamjpharm.org/trabajos/28/3/LAJOP_28_3_1_12_HFO4TCESP6.pdf
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bdutipo_str	Repositorios
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Preparation and evaluation of W/O/W multiple emulsion containing naltrexone hydrochloride: a pilot study

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