Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model

Adipose tissue (AT) expansion is the result of two processes: hyperplasia and hypertrophy; and both, directly or indirectly, depend on the adipogenic potential of adipocyte precursor cells (APCs). Glucocorticoids (GCs) have a potent stimulatory effect on terminal adipogenesis; while their effects on...

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Autores principales: Zubiría, María Guillermina, Alzamendi, Ana, Moreno, Griselda, Portales, Andrea Estefanía, Castrogiovanni, Daniel Cayetano, Spinedi, Eduardo Julio, Giovambattista, Andrés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
retroperitoneal adipose tissue; adipogenesis; stromal vascular fraction cells; cell determination; adipogenic competency
Tejido Adiposo
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/77690
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-77690
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
retroperitoneal adipose tissue; adipogenesis; stromal vascular fraction cells; cell determination; adipogenic competency
Tejido Adiposo
spellingShingle Ciencias Médicas
retroperitoneal adipose tissue; adipogenesis; stromal vascular fraction cells; cell determination; adipogenic competency
Tejido Adiposo
Zubiría, María Guillermina
Alzamendi, Ana
Moreno, Griselda
Portales, Andrea Estefanía
Castrogiovanni, Daniel Cayetano
Spinedi, Eduardo Julio
Giovambattista, Andrés
Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
topic_facet Ciencias Médicas
retroperitoneal adipose tissue; adipogenesis; stromal vascular fraction cells; cell determination; adipogenic competency
Tejido Adiposo
description Adipose tissue (AT) expansion is the result of two processes: hyperplasia and hypertrophy; and both, directly or indirectly, depend on the adipogenic potential of adipocyte precursor cells (APCs). Glucocorticoids (GCs) have a potent stimulatory effect on terminal adipogenesis; while their effects on early stages of adipogenesis are largely unknown. In the present work, we study, in a model of high GC levels, the adipogenic potential of APCs from retroperitoneal AT (RPAT) and its relationship with RPAT mass expansion. We employed a model of hyper-adiposity (30- and 60-day-old rats) due to high endogenous GC levels induced by neonatal treatment with L-monosodium glutamate (MSG).We found that the RPAT APCs from 30-day-old MSG rats showed an increased adipogenic capacity, depending on the APCs’ competency, but not in their number. Analyses of RPAT adipocyte diameter revealed an increase in cell size, regardless of the rat age, indicating the prevalence of a hypertrophic process. Moreover, functional RPAT alterations worsened in 60-day-old rats, suggesting that the hyperplastic AT expansion found in 30-day-old animals might have a protective role. We conclude that GCs chronic excess affects APCs’ adipogenic capacity, modifying their competency. This change would modulate the hyperplastic/hypertrophic balance determining healthy or unhealthy RPAT expansion and, therefore, its functionality.
format Articulo
Articulo
author Zubiría, María Guillermina
Alzamendi, Ana
Moreno, Griselda
Portales, Andrea Estefanía
Castrogiovanni, Daniel Cayetano
Spinedi, Eduardo Julio
Giovambattista, Andrés
author_facet Zubiría, María Guillermina
Alzamendi, Ana
Moreno, Griselda
Portales, Andrea Estefanía
Castrogiovanni, Daniel Cayetano
Spinedi, Eduardo Julio
Giovambattista, Andrés
author_sort Zubiría, María Guillermina
title Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
title_short Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
title_full Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
title_fullStr Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
title_full_unstemmed Relationship between the Balance of Hypertrophic/Hyperplastic Adipose Tissue Expansion and the Metabolic Profile in a High Glucocorticoids Model
title_sort relationship between the balance of hypertrophic/hyperplastic adipose tissue expansion and the metabolic profile in a high glucocorticoids model
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/77690
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