Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design
The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3<sup>2</sup> factorial design were investigated with a view to deve...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7754 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_13_JOK94G603E.pdf |
| Aporte de: |
| Sumario: | The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3<sup>2</sup> factorial design were investigated with a view to develop mucoadhesive microspheres of controlled release. The resulting microspheres were discrete, free flowing, spherical and multinucleate monolithic type. Microencapsulation efficiency was in the range of 56-88%. Microspheres exhibit good mucoadhesive property in the falling film test. Glipizide release from the mucoadhesive microspheres was slow and extended over long period of time. Drug release was non-Fickian type. The concentration of carbopol 971P and sodium alginate had a more significant effect on different variables. In-vivo testing demonstrated a significant hypoglycemic effect of glipizide |
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