Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design
The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3<sup>2</sup> factorial design were investigated with a view to deve...
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7754 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_13_JOK94G603E.pdf |
| Aporte de: |
| id |
I19-R120-10915-7754 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia factorial design; glipizide; mucoadhesive microspheres Productos químicos y drogas |
| spellingShingle |
Farmacia factorial design; glipizide; mucoadhesive microspheres Productos químicos y drogas Hosmani, Avinash H. Kasture, Pramod V. Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| topic_facet |
Farmacia factorial design; glipizide; mucoadhesive microspheres Productos químicos y drogas |
| description |
The purpose of the research was to prepare controlled release glipizide mucoadhesive microspheres with a coat consisting of sodium alginate and a mucoadhesive polymer Carbopol 971P. Orificeionic gelation method by using 3<sup>2</sup> factorial design were investigated with a view to develop mucoadhesive microspheres of controlled release. The resulting microspheres were discrete, free flowing, spherical and multinucleate monolithic type. Microencapsulation efficiency was in the range of 56-88%. Microspheres exhibit good mucoadhesive property in the falling film test. Glipizide release from the mucoadhesive microspheres was slow and extended over long period of time. Drug release was non-Fickian type. The concentration of carbopol 971P and sodium alginate had a more significant effect on different variables. In-vivo testing demonstrated a significant hypoglycemic effect of glipizide |
| format |
Articulo Articulo |
| author |
Hosmani, Avinash H. Kasture, Pramod V. |
| author_facet |
Hosmani, Avinash H. Kasture, Pramod V. |
| author_sort |
Hosmani, Avinash H. |
| title |
Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| title_short |
Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| title_full |
Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| title_fullStr |
Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| title_full_unstemmed |
Preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| title_sort |
preparation and in vitro and in vivo evaluation of glipizide mucoadhesive microspheres using factorial design |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7754 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_13_JOK94G603E.pdf |
| work_keys_str_mv |
AT hosmaniavinashh preparationandinvitroandinvivoevaluationofglipizidemucoadhesivemicrospheresusingfactorialdesign AT kasturepramodv preparationandinvitroandinvivoevaluationofglipizidemucoadhesivemicrospheresusingfactorialdesign |
| bdutipo_str |
Repositorios |
| _version_ |
1764820484640210944 |