Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia

The hexanic and ethanolic extracts obtained from Rollinia laurifolia, collected in Minas Gerais State/Brazil, were screened by the brine shrimp lethality and cytotoxic assays on different cell lines, in order to identify potential sources for novel antitumoral compounds. Fifty percent of the ethanol...

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Detalles Bibliográficos
Autores principales: Cunha, M. M., Nascimento, F. C., Santos Pimento, L. P., Boaventura, M. A. D., Salas, C. E., Lopes, M. T. P.
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
annonaceae; acetogenins; cytotoxic activity; rollinia laurifolia
Extractos de plantas
Ensayos
Test de Citotoxicidad
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7751
http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_10_M2NU25E601.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7751
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
annonaceae; acetogenins; cytotoxic activity; rollinia laurifolia
Extractos de plantas
Ensayos
Test de Citotoxicidad
spellingShingle Farmacia
annonaceae; acetogenins; cytotoxic activity; rollinia laurifolia
Extractos de plantas
Ensayos
Test de Citotoxicidad
Cunha, M. M.
Nascimento, F. C.
Santos Pimento, L. P.
Boaventura, M. A. D.
Salas, C. E.
Lopes, M. T. P.
Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
topic_facet Farmacia
annonaceae; acetogenins; cytotoxic activity; rollinia laurifolia
Extractos de plantas
Ensayos
Test de Citotoxicidad
description The hexanic and ethanolic extracts obtained from Rollinia laurifolia, collected in Minas Gerais State/Brazil, were screened by the brine shrimp lethality and cytotoxic assays on different cell lines, in order to identify potential sources for novel antitumoral compounds. Fifty percent of the ethanolic derived fractions (E) showed significant cytotoxic activity (IC<sub>50</sub> < 10–1 μg/mL), not related to tannins or saponins, i. e., IC<sub>50</sub> E13 on C6 = 1.54 x 10<sup>-2</sup> μg/mL, IC<sub>50</sub> E29 on L<sub>929</sub> and C<sub>6</sub> = 6.43 x 10<sup>-1</sup> μg/mL and 3.57 x 10<sup>-2</sup> μg/mL, respectively. RP-HPLC analysis led to the purification and identification of two known acetogenins, gonionenin and annonin-I, detected for the first time in Rollinia sp, and a new acetogenin, named laurifolin.
format Articulo
Articulo
author Cunha, M. M.
Nascimento, F. C.
Santos Pimento, L. P.
Boaventura, M. A. D.
Salas, C. E.
Lopes, M. T. P.
author_facet Cunha, M. M.
Nascimento, F. C.
Santos Pimento, L. P.
Boaventura, M. A. D.
Salas, C. E.
Lopes, M. T. P.
author_sort Cunha, M. M.
title Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
title_short Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
title_full Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
title_fullStr Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
title_full_unstemmed Screening of cytotoxic activity in hexanic and ethanolic extracts of Rollinia laurifolia
title_sort screening of cytotoxic activity in hexanic and ethanolic extracts of rollinia laurifolia
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7751
http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_10_M2NU25E601.pdf
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