Dissolution rate enhancement of fenofibrate using liquisolid tablet technique
Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of p...
Guardado en:
| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7749 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_8_SLMR1NB89L.pdf |
| Aporte de: |
| id |
I19-R120-10915-7749 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Medicamento dissolution rate; drug release; liquisolid tablets; poorly water soluble drug |
| spellingShingle |
Farmacia Medicamento dissolution rate; drug release; liquisolid tablets; poorly water soluble drug Karmarkar, Amrit B. Gonjari, Indrajeet D. Hosmani, Avinash H. Dhabale, Pandurang N. Bhise, Satish B. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| topic_facet |
Farmacia Medicamento dissolution rate; drug release; liquisolid tablets; poorly water soluble drug |
| description |
Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formulation into liquisolid tablets and then to investigate in vitro performance of prepared liquisolid systems. By use of this technique, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be easily converted into powders with acceptable flow properties and compression behavior by using suitable powder excipients. X-ray powder diffraction and Differential Scanning Calorimetry were used for evaluation of physicochemical properties of Fenofibrate in liquisolid tablets. Stereomicroscopy was used to assess morphological characteristics of liquisolid formulation. Enhanced drug release profiles due to increased wetting properties and surface of drug available for dissolution was obtained in case of liquisolid tablets. |
| format |
Articulo Articulo |
| author |
Karmarkar, Amrit B. Gonjari, Indrajeet D. Hosmani, Avinash H. Dhabale, Pandurang N. Bhise, Satish B. |
| author_facet |
Karmarkar, Amrit B. Gonjari, Indrajeet D. Hosmani, Avinash H. Dhabale, Pandurang N. Bhise, Satish B. |
| author_sort |
Karmarkar, Amrit B. |
| title |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| title_short |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| title_full |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| title_fullStr |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| title_full_unstemmed |
Dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| title_sort |
dissolution rate enhancement of fenofibrate using liquisolid tablet technique |
| publishDate |
2009 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7749 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_8_SLMR1NB89L.pdf |
| work_keys_str_mv |
AT karmarkaramritb dissolutionrateenhancementoffenofibrateusingliquisolidtablettechnique AT gonjariindrajeetd dissolutionrateenhancementoffenofibrateusingliquisolidtablettechnique AT hosmaniavinashh dissolutionrateenhancementoffenofibrateusingliquisolidtablettechnique AT dhabalepandurangn dissolutionrateenhancementoffenofibrateusingliquisolidtablettechnique AT bhisesatishb dissolutionrateenhancementoffenofibrateusingliquisolidtablettechnique |
| bdutipo_str |
Repositorios |
| _version_ |
1764820484483973120 |