In vivo xylitol primary dermal irritation and phototoxicity evaluation

Xylitol is a widely studied sugar with therapeutic properties and is effective against microorganisms. Despite a variety of toxicological data being available about this compound, dermal toxicological tests cannot be found. Here, the aim was to carry out in vivo assays to verify xylitol skin applica...

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Detalles Bibliográficos
Autores principales:	Ferreira, Aline S., Barbosa, Nádia R., Silva, Silvio S
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2009
Materias:	Farmacia Toxicología pharmaceutical preparations; phototoxicity; primary dermal irritation study; xylitol Medicamento Composición de medicamentos Evaluación de Medicamentos Farmacología
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/7745 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_4_Y0R1N0PXBL.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-7745
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Farmacia Toxicología pharmaceutical preparations; phototoxicity; primary dermal irritation study; xylitol Medicamento Composición de medicamentos Evaluación de Medicamentos Farmacología
spellingShingle	Farmacia Toxicología pharmaceutical preparations; phototoxicity; primary dermal irritation study; xylitol Medicamento Composición de medicamentos Evaluación de Medicamentos Farmacología Ferreira, Aline S. Barbosa, Nádia R. Silva, Silvio S In vivo xylitol primary dermal irritation and phototoxicity evaluation
topic_facet	Farmacia Toxicología pharmaceutical preparations; phototoxicity; primary dermal irritation study; xylitol Medicamento Composición de medicamentos Evaluación de Medicamentos Farmacología
description	Xylitol is a widely studied sugar with therapeutic properties and is effective against microorganisms. Despite a variety of toxicological data being available about this compound, dermal toxicological tests cannot be found. Here, the aim was to carry out in vivo assays to verify xylitol skin application safety. Primary dermal irritation studies were done with rabbits using 5 and 10% (w/w) xylitol, in either cream or gel form. Phototoxicity assays were also performed with guinea pigs, using only 10% (w/w) xylitol, in both forms. Primary dermal irritation studies revealed that xylitol topically used (5 and 10%) did not induce erythema or edema formation, but did show phototoxicity properties. Xylitol is an adequate alternative compound to be applied for skin disease control, since this application will be done together with sunscreen.
format	Articulo Articulo
author	Ferreira, Aline S. Barbosa, Nádia R. Silva, Silvio S
author_facet	Ferreira, Aline S. Barbosa, Nádia R. Silva, Silvio S
author_sort	Ferreira, Aline S.
title	In vivo xylitol primary dermal irritation and phototoxicity evaluation
title_short	In vivo xylitol primary dermal irritation and phototoxicity evaluation
title_full	In vivo xylitol primary dermal irritation and phototoxicity evaluation
title_fullStr	In vivo xylitol primary dermal irritation and phototoxicity evaluation
title_full_unstemmed	In vivo xylitol primary dermal irritation and phototoxicity evaluation
title_sort	in vivo xylitol primary dermal irritation and phototoxicity evaluation
publishDate	2009
url	http://sedici.unlp.edu.ar/handle/10915/7745 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_4_Y0R1N0PXBL.pdf
work_keys_str_mv	AT ferreiraalines invivoxylitolprimarydermalirritationandphototoxicityevaluation AT barbosanadiar invivoxylitolprimarydermalirritationandphototoxicityevaluation AT silvasilvios invivoxylitolprimarydermalirritationandphototoxicityevaluation
bdutipo_str	Repositorios
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In vivo xylitol primary dermal irritation and phototoxicity evaluation

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