Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
The viability of employing flow analysis coupled to Fourier transform infrared spectroscopy (FA-FTIR) as a useful tool for quantitative measuring of magnesium sulphate in pharmaceuticals was explored, developed and validated. The method was based on mid-IR transmittance measurements of the peak-area...
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| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7743 http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_2_08C91ACD3F.pdf |
| Aporte de: |
| Sumario: | The viability of employing flow analysis coupled to Fourier transform infrared spectroscopy (FA-FTIR) as a useful tool for quantitative measuring of magnesium sulphate in pharmaceuticals was explored, developed and validated. The method was based on mid-IR transmittance measurements of the peak-area belonging to the sulphate band around 1110 cm–1 and the use of an external calibration curve. Dynamic range was established over a concentration range from 1 to 50 mg.ml–1 , with a limit of detection (3σ) of 0.26 mg.ml–1 The analytical frequency was 12 h–1 with a precision close to the unit (% RSD). The . analytical results obtained in commercial formulations by applying the proposed FA-FTIR method were in strong agreement with labelled values and those obtained by a reference titration method at 95% confidence level. Among various advantages offered by the proposed method over conventional ones, simple strategy and clean analytical chemistry must been highlighted. |
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