Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy

The viability of employing flow analysis coupled to Fourier transform infrared spectroscopy (FA-FTIR) as a useful tool for quantitative measuring of magnesium sulphate in pharmaceuticals was explored, developed and validated. The method was based on mid-IR transmittance measurements of the peak-area...

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Autores principales: Ovalles, Fernando, Gallignani, Máximo, Rondón, Rebeca, Brunetto, Maria R., Luna, Rafael
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7743
http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_2_08C91ACD3F.pdf
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id I19-R120-10915-7743
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
epsom salt; flow analysis; fourier transforms infrared; magnesium sulphate; pharmaceutical analysis
Farmacología
Aplicaciones terapeúticas
spellingShingle Farmacia
epsom salt; flow analysis; fourier transforms infrared; magnesium sulphate; pharmaceutical analysis
Farmacología
Aplicaciones terapeúticas
Ovalles, Fernando
Gallignani, Máximo
Rondón, Rebeca
Brunetto, Maria R.
Luna, Rafael
Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
topic_facet Farmacia
epsom salt; flow analysis; fourier transforms infrared; magnesium sulphate; pharmaceutical analysis
Farmacología
Aplicaciones terapeúticas
description The viability of employing flow analysis coupled to Fourier transform infrared spectroscopy (FA-FTIR) as a useful tool for quantitative measuring of magnesium sulphate in pharmaceuticals was explored, developed and validated. The method was based on mid-IR transmittance measurements of the peak-area belonging to the sulphate band around 1110 cm–1 and the use of an external calibration curve. Dynamic range was established over a concentration range from 1 to 50 mg.ml–1 , with a limit of detection (3σ) of 0.26 mg.ml–1 The analytical frequency was 12 h–1 with a precision close to the unit (% RSD). The . analytical results obtained in commercial formulations by applying the proposed FA-FTIR method were in strong agreement with labelled values and those obtained by a reference titration method at 95% confidence level. Among various advantages offered by the proposed method over conventional ones, simple strategy and clean analytical chemistry must been highlighted.
format Articulo
Articulo
author Ovalles, Fernando
Gallignani, Máximo
Rondón, Rebeca
Brunetto, Maria R.
Luna, Rafael
author_facet Ovalles, Fernando
Gallignani, Máximo
Rondón, Rebeca
Brunetto, Maria R.
Luna, Rafael
author_sort Ovalles, Fernando
title Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
title_short Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
title_full Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
title_fullStr Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
title_full_unstemmed Determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
title_sort determination of sulphate for measuring magnesium sulphate in pharmaceuticals by flow analysis-fourier transforms infrared spectroscopy
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7743
http://www.latamjpharm.org/trabajos/28/2/LAJOP_28_2_1_2_08C91ACD3F.pdf
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