Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process

The aim this work was develop gastro-resistant pellets of didanosine as well as study the impact on the pellets properties, regarding the way as the binder was added and drying process used. The pellets formation was accompanied by analysis of morphological parameters and didanosine dissolution. In...

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Detalles Bibliográficos
Autores principales: Andréo Filho, Newton, Pessole, Letícia, Issa, Michele, Villela, Cláudio, Ferraz, Humberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Medicamento
didanosine; extrusion; gastro-resistant dosage form; pellets; spheronization
Formas de Dosificación
Inosina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7722
http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_5_SR0F62J9FA.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7722
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Medicamento
didanosine; extrusion; gastro-resistant dosage form; pellets; spheronization
Formas de Dosificación
Inosina
spellingShingle Farmacia
Medicamento
didanosine; extrusion; gastro-resistant dosage form; pellets; spheronization
Formas de Dosificación
Inosina
Andréo Filho, Newton
Pessole, Letícia
Issa, Michele
Villela, Cláudio
Ferraz, Humberto
Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
topic_facet Farmacia
Medicamento
didanosine; extrusion; gastro-resistant dosage form; pellets; spheronization
Formas de Dosificación
Inosina
description The aim this work was develop gastro-resistant pellets of didanosine as well as study the impact on the pellets properties, regarding the way as the binder was added and drying process used. The pellets formation was accompanied by analysis of morphological parameters and didanosine dissolution. In the most cases, pellets showed diameter around 1.0 mm and shape parameters acceptable. The variations of the process did not interfere significantly in pellets size. In turn, drying in fluid bed favored the dissolution of didanosine, in contrast to binder addition on powder form that impaired. In another hand, this last resulted in the best aspect factor (about 1.1). Gastro-resistant pellets showed adequate dissolution, compatible with this type of dosage form. The variables of process studied enabled obtain pellets with characteristics of shape and dissolution just slightly different, indicating flexibility of the formulation for production of gastro-resistant pellets of didanosine.
format Articulo
Articulo
author Andréo Filho, Newton
Pessole, Letícia
Issa, Michele
Villela, Cláudio
Ferraz, Humberto
author_facet Andréo Filho, Newton
Pessole, Letícia
Issa, Michele
Villela, Cláudio
Ferraz, Humberto
author_sort Andréo Filho, Newton
title Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
title_short Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
title_full Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
title_fullStr Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
title_full_unstemmed Gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
title_sort gastro-resistant pellets of didanosine obtained by extrusion and spheronization: assessing the production process
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7722
http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_5_SR0F62J9FA.pdf
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