Protective effect of D-003 on renal ischemia-reperfusion in rats
The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage, were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham oper...
Guardado en:
| Autores principales: | , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7718 http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_1_9BG1IL2E80.pdf |
| Aporte de: |
| Sumario: | The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with
antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage,
were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham operation
or renal I/R. One group was treated orally with the vehicle, two were treated with D-003 (250 and 500
mg/kg) and other with GSE (200 mg/kg). Renal morphological alterations were assessed by histopathological
examination of haematoxylin-eosin stained. After 24 h of post-ischemic acute renal failure, serum creatinine
levels was increased, effect that was significantly decreased by about 30 % and 60 % with D-003
and with GSE, respectively. Compared with sham rats, ischemic controls demonstrated severe damage of
renal function and morphology, while both D-003 and GSE treatments protected against these I/R-induced
histological abnormalities too. D-003 protected moderately against the increase of serum creatinine and
histological findings of I/R-induced renal injury in rats. |
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