Protective effect of D-003 on renal ischemia-reperfusion in rats

The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage, were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham oper...

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Autores principales: Carbajal, Daisy, Noa, Miriam, Ravelo, Yazmin, Arruzazabala, María de Lourdes, Más, Rosa, Valle, Maikel, Mendoza, Nilda
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Farmacia
Medicamento
creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax
Farmacología
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7718
http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_1_9BG1IL2E80.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7718
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
Medicamento
creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax
Farmacología
spellingShingle Farmacia
Medicamento
creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax
Farmacología
Carbajal, Daisy
Noa, Miriam
Ravelo, Yazmin
Arruzazabala, María de Lourdes
Más, Rosa
Valle, Maikel
Mendoza, Nilda
Protective effect of D-003 on renal ischemia-reperfusion in rats
topic_facet Farmacia
Medicamento
creatinine; D-003, grape seed extract; ischemia-reperfusion; renal failure; sugarcane wax
Farmacología
description The effects of D-003, a mixture of higher aliphatic acids purified from sugarcane wax with antioxidant effects, and a grape seed extracts (GSE) on serum creatinine levels and on histological damage, were evaluated in a rat model of renal ischemia-reperfusion (I/R). Rats were subjected to sham operation or renal I/R. One group was treated orally with the vehicle, two were treated with D-003 (250 and 500 mg/kg) and other with GSE (200 mg/kg). Renal morphological alterations were assessed by histopathological examination of haematoxylin-eosin stained. After 24 h of post-ischemic acute renal failure, serum creatinine levels was increased, effect that was significantly decreased by about 30 % and 60 % with D-003 and with GSE, respectively. Compared with sham rats, ischemic controls demonstrated severe damage of renal function and morphology, while both D-003 and GSE treatments protected against these I/R-induced histological abnormalities too. D-003 protected moderately against the increase of serum creatinine and histological findings of I/R-induced renal injury in rats.
format Articulo
Articulo
author Carbajal, Daisy
Noa, Miriam
Ravelo, Yazmin
Arruzazabala, María de Lourdes
Más, Rosa
Valle, Maikel
Mendoza, Nilda
author_facet Carbajal, Daisy
Noa, Miriam
Ravelo, Yazmin
Arruzazabala, María de Lourdes
Más, Rosa
Valle, Maikel
Mendoza, Nilda
author_sort Carbajal, Daisy
title Protective effect of D-003 on renal ischemia-reperfusion in rats
title_short Protective effect of D-003 on renal ischemia-reperfusion in rats
title_full Protective effect of D-003 on renal ischemia-reperfusion in rats
title_fullStr Protective effect of D-003 on renal ischemia-reperfusion in rats
title_full_unstemmed Protective effect of D-003 on renal ischemia-reperfusion in rats
title_sort protective effect of d-003 on renal ischemia-reperfusion in rats
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/7718
http://www.latamjpharm.org/trabajos/28/1/LAJOP_28_1_1_1_9BG1IL2E80.pdf
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bdutipo_str Repositorios
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