Alternative technologies to improve solubility of poorly water soluble drugs

The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size t...

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Autores principales: Lima, Ádley A. N., Sobrinho, José L.S., Corrêa Jr, Roberto A.C., Rolim Neto, Pedró José
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2008
Materias:
Farmacia
cyclodextrins; inclusion complexes; polymers; solid dispersion; solubility
Farmacología
Evaluación de medicamentos
Solubilidad
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/7693
http://www.latamjpharm.org/trabajos/27/5/LAJOP_27_5_4_2_7QVYB4J43B.pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-7693
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Farmacia
cyclodextrins; inclusion complexes; polymers; solid dispersion; solubility
Farmacología
Evaluación de medicamentos
Solubilidad
spellingShingle Farmacia
cyclodextrins; inclusion complexes; polymers; solid dispersion; solubility
Farmacología
Evaluación de medicamentos
Solubilidad
Lima, Ádley A. N.
Sobrinho, José L.S.
Corrêa Jr, Roberto A.C.
Rolim Neto, Pedró José
Alternative technologies to improve solubility of poorly water soluble drugs
topic_facet Farmacia
cyclodextrins; inclusion complexes; polymers; solid dispersion; solubility
Farmacología
Evaluación de medicamentos
Solubilidad
description The solubility behaviour of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes (IC) are two of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, bioavailability may be significantly improved. The basis for this popularity from a pharmaceutical standpoint, is the ability of these materials to interact with poorly water-soluble drugs and drug candidates resulting in an increase in their apparent water solubility. This review is intended to give a general background to the use of cyclodextrins (CD) and solid dispersions as alternative technologies in the study of drug solubilization.
format Articulo
Revision
author Lima, Ádley A. N.
Sobrinho, José L.S.
Corrêa Jr, Roberto A.C.
Rolim Neto, Pedró José
author_facet Lima, Ádley A. N.
Sobrinho, José L.S.
Corrêa Jr, Roberto A.C.
Rolim Neto, Pedró José
author_sort Lima, Ádley A. N.
title Alternative technologies to improve solubility of poorly water soluble drugs
title_short Alternative technologies to improve solubility of poorly water soluble drugs
title_full Alternative technologies to improve solubility of poorly water soluble drugs
title_fullStr Alternative technologies to improve solubility of poorly water soluble drugs
title_full_unstemmed Alternative technologies to improve solubility of poorly water soluble drugs
title_sort alternative technologies to improve solubility of poorly water soluble drugs
publishDate 2008
url http://sedici.unlp.edu.ar/handle/10915/7693
http://www.latamjpharm.org/trabajos/27/5/LAJOP_27_5_4_2_7QVYB4J43B.pdf
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