Correlation between Diazepam in plasma and dose in patients in long-term treatment
Diazepam, a benzodiazepine drug, has many therapeutic uses but little is known about the diazepam dose/plasma level ratio when the drug is administered for a long period of time. In the present study we determined plasma diazepam concentration in 26 patients receiving 5 and 10 mg/day of the drug. A...
Guardado en:
| Autores principales: | , , , |
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| Formato: | Articulo Comunicacion |
| Lenguaje: | Inglés |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7689 http://www.latamjpharm.org/resumenes/27/5/LAJOP_27_5_2_4.pdf |
| Aporte de: |
| id |
I19-R120-10915-7689 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Farmacia Diazepam; drug monitoring; gas chromatography; plasmatic concentration Farmacología Efectos fisiológicos de las drogas Evaluación de drogas |
| spellingShingle |
Farmacia Diazepam; drug monitoring; gas chromatography; plasmatic concentration Farmacología Efectos fisiológicos de las drogas Evaluación de drogas Silvério, Alessandra C.P. Urias, Tatiane S. Martins, Isarita Siqueira, Maria E.P.B. Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| topic_facet |
Farmacia Diazepam; drug monitoring; gas chromatography; plasmatic concentration Farmacología Efectos fisiológicos de las drogas Evaluación de drogas |
| description |
Diazepam, a benzodiazepine drug, has many therapeutic uses but little is known about the diazepam dose/plasma level ratio when the drug is administered for a long period of time. In the present study we determined plasma diazepam concentration in 26 patients receiving 5 and 10 mg/day of the drug.
A gas chromatography/electron-capture detector method was validated for diazepam quantification in plasma using an OV 17-3% in Chromosorb W 80/100 mesh column. The use of 70:30 n-hexane: dichoromethane (v/v) as extraction solvent yielded good results. The following data were obtained: linearity from 10 to 1000 ng mL–1, detection and quantification limits of 5 and 10 ng.mL–1, respectively; intra and interassay average precision of 4.6 and 7.9%, respectively, mean recovery of 80.6%. The drug remained stable in the plasma sample for at least 30 days when stored at -20 °C. The relation between dose and plasma concentration did not increase in linearity when the dose was increased. |
| format |
Articulo Comunicacion |
| author |
Silvério, Alessandra C.P. Urias, Tatiane S. Martins, Isarita Siqueira, Maria E.P.B. |
| author_facet |
Silvério, Alessandra C.P. Urias, Tatiane S. Martins, Isarita Siqueira, Maria E.P.B. |
| author_sort |
Silvério, Alessandra C.P. |
| title |
Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| title_short |
Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| title_full |
Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| title_fullStr |
Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| title_full_unstemmed |
Correlation between Diazepam in plasma and dose in patients in long-term treatment |
| title_sort |
correlation between diazepam in plasma and dose in patients in long-term treatment |
| publishDate |
2008 |
| url |
http://sedici.unlp.edu.ar/handle/10915/7689 http://www.latamjpharm.org/resumenes/27/5/LAJOP_27_5_2_4.pdf |
| work_keys_str_mv |
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Repositorios |
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