Desenvolvimento e validação de método de dissolução para deflazacorte em comprimidos e cápsulas magistrais
The aim of this work was to develop and validate a dissolution test for deflazacort in tablets and compounding capsules using spectrophotometric method. The dissolution established conditions were: 900 mL of 0,1M HCl as dissolution medium, using a paddle apparatus for tablets and basket apparatus...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Portugués |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/7679 http://www.latamjpharm.org/trabajos/27/5/LAJOP_27_5_1_14_0X7D629OE2.pdf |
| Aporte de: |
| Sumario: | The aim of this work was to develop and validate a dissolution test for deflazacort in tablets and compounding
capsules using spectrophotometric method. The dissolution established conditions were: 900 mL of
0,1M HCl as dissolution medium, using a paddle apparatus for tablets and basket apparatus for capsules at a stirring
rate of 50 rpm. The % drug release was evaluated by UV spectrophotometric method at 244 nm. The method
was validated and showed be specific, linear, precise and accurate. In addition, filter influence and drug stability
in dissolution medium were also evaluated. |
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