Lipid composition of normal male rat islets

Lipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were...

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Autores principales: Díaz, Graciela, Cortizo, Ana María, García, María Elisa, Gagliardino, Juan José
Formato: Articulo
Lenguaje:Inglés
Publicado: 1988
Materias:
Ciencias Médicas
Lípidos
Páncreas
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/76582
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-76582
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Lípidos
Páncreas
spellingShingle Ciencias Médicas
Lípidos
Páncreas
Díaz, Graciela
Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
Lipid composition of normal male rat islets
topic_facet Ciencias Médicas
Lípidos
Páncreas
description Lipid composition was studied in fresh isolated isolets from normal male rats. Extractable lipids represent 1856 μg per mg islet protein. In such extracts, phospholipids and neutral lipids reprsent 13.5% and 86.5%, respectively. Phosphatidylcholine (45.8%) and phosphatidyl-ethanolamine (20.6%) were the major components of the phospholipid fraction, and phosphatidylinositol (8.9%) was the minor component. Esterified cholesterol (38.5%), cholesterol (25.5%) and free fatty acids (24.4%) were the major components of the neutral lipid fraction. Fatty major components of the neutral lipid fraction. Fatty acids esterified to phospholipids account for 619.7 pmol/islet, and, 2710 pmol/islet were esterified to neutral lipids. In the phospholipid fraction, saturated and unsaturated fatty acids were in a similar proportion. Conversely, in the neutral lipids, two-thirds of the fatty acids were unsaturated. The ω6 family was the main component of the phospholipid unsaturated fatty acids. In the ω6 and ω3 families, the long-chain fatty acids represent the main components. In the neutral lipid fraction, a different percentage of each family was found: ω3>ω6>ω9. The long-chain polyunsaturated fatty acids were also predominant species in the ω6 and ω3 families. Further studies on the lipid composition of islets, obtained from rats with normal and altered islet functions, could provide new insights into the knowledge of the mechanism of insulin secretion.
format Articulo
Articulo
author Díaz, Graciela
Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
author_facet Díaz, Graciela
Cortizo, Ana María
García, María Elisa
Gagliardino, Juan José
author_sort Díaz, Graciela
title Lipid composition of normal male rat islets
title_short Lipid composition of normal male rat islets
title_full Lipid composition of normal male rat islets
title_fullStr Lipid composition of normal male rat islets
title_full_unstemmed Lipid composition of normal male rat islets
title_sort lipid composition of normal male rat islets
publishDate 1988
url http://sedici.unlp.edu.ar/handle/10915/76582
work_keys_str_mv AT diazgraciela lipidcompositionofnormalmaleratislets
AT cortizoanamaria lipidcompositionofnormalmaleratislets
AT garciamariaelisa lipidcompositionofnormalmaleratislets
AT gagliardinojuanjose lipidcompositionofnormalmaleratislets
bdutipo_str Repositorios
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