Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells
The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Simi...
Guardado en:
| Autores principales: | , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
1995
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/76578 |
| Aporte de: |
| id |
I19-R120-10915-76578 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Química Vanadio vanadium compounds, osteoblast-like cells, proliferation, differentiation, bone development, growth factors |
| spellingShingle |
Ciencias Exactas Química Vanadio vanadium compounds, osteoblast-like cells, proliferation, differentiation, bone development, growth factors Cortizo, Ana María Etcheverry, Susana B. Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells |
| topic_facet |
Ciencias Exactas Química Vanadio vanadium compounds, osteoblast-like cells, proliferation, differentiation, bone development, growth factors |
| description |
The effect of different vanadium compounds on proliferation and differentiation was examined in osteoblast-like UMR106 cells. Vanadate increased the cell growth in a biphasic manner, the higher doses inhibiting cell progression. Vanadyl stimulated cell proliferation in a dose-responsive manner. Similar to vanadate, pervanadate increased osteoblast-like cell proliferation in a biphasic manner but no inhibition of growth was observed. Vanadyl and pervanadate were stronger stimulators of cell growth than vanadate. Only vanadate was able to regulate the cell differentiation as measured by cell alkaline phosphatase activity. These results suggest that vanadium derivatives behave like growth factors on osteoblast-like cells and are potential pharmacological tools in the control of cell growth. |
| format |
Articulo Articulo |
| author |
Cortizo, Ana María Etcheverry, Susana B. |
| author_facet |
Cortizo, Ana María Etcheverry, Susana B. |
| author_sort |
Cortizo, Ana María |
| title |
Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like UMR106 cells |
| title_short |
Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like UMR106 cells |
| title_full |
Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like UMR106 cells |
| title_fullStr |
Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like UMR106 cells |
| title_full_unstemmed |
Vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like UMR106 cells |
| title_sort |
vanadium derivatives act as growth factor-mimetic compounds upon differentiation and
proliferation of osteoblast-like umr106 cells |
| publishDate |
1995 |
| url |
http://sedici.unlp.edu.ar/handle/10915/76578 |
| work_keys_str_mv |
AT cortizoanamaria vanadiumderivativesactasgrowthfactormimeticcompoundsupondifferentiationandproliferationofosteoblastlikeumr106cells AT etcheverrysusanab vanadiumderivativesactasgrowthfactormimeticcompoundsupondifferentiationandproliferationofosteoblastlikeumr106cells |
| bdutipo_str |
Repositorios |
| _version_ |
1764820484348706817 |