Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients

The aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments car...

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Detalles Bibliográficos
Autores principales:	Cortizo, María Cecilia, Fernández Lorenzo de Mele, Mónica Alicia
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2004
Materias:	Odontología biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period Materiales Biomédicos y Dentales
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/76476
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-76476
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Odontología biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period Materiales Biomédicos y Dentales
spellingShingle	Odontología biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period Materiales Biomédicos y Dentales Cortizo, María Cecilia Fernández Lorenzo de Mele, Mónica Alicia Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
topic_facet	Odontología biocompatibility; cytotoxicity; copper; biomaterial; released ions; exposure period Materiales Biomédicos y Dentales
description	The aim of this work is to contribute to the elucidation of the cytotoxic process caused by the copper ions released from the biomaterials. Clonal cell lines UMR106 were used in the experiments. Copper ions were obtained from two different sources: copper salts and metal dissolution. Experiments carried out with constant ion concentrations (copper salts) were compared with those with concentrations that vary with time and location (dissolution of the metal). Present results and others previously reported could be interpreted through mathematical models that describe: (1) the variation of concentration of copper ions with time and location within a biofilm and (2) the variation of the killing rate with the concentration of the toxic ion and time. The large number of dead cells found near the copper sample with an average ion concentration below the toxic limit could be interpreted bearing in mind that these cells should be exposed to a local concentration higher than this limit. A logarithmic dependence between the number of cells and exposure time was found for nearly constant ion concentrations. Apparent discrepancies, observed when these results and those of different researchers were contrasted, could be explained considering the dissimilar experimental conditions such as the source of the ions and their local concentration at real time.
format	Articulo Articulo
author	Cortizo, María Cecilia Fernández Lorenzo de Mele, Mónica Alicia
author_facet	Cortizo, María Cecilia Fernández Lorenzo de Mele, Mónica Alicia
author_sort	Cortizo, María Cecilia
title	Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_short	Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_full	Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_fullStr	Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_full_unstemmed	Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients
title_sort	cytotoxicity of copper ions released from metal : variation with the exposure period and concentration gradients
publishDate	2004
url	http://sedici.unlp.edu.ar/handle/10915/76476
work_keys_str_mv	AT cortizomariacecilia cytotoxicityofcopperionsreleasedfrommetalvariationwiththeexposureperiodandconcentrationgradients AT fernandezlorenzodemelemonicaalicia cytotoxicityofcopperionsreleasedfrommetalvariationwiththeexposureperiodandconcentrationgradients
bdutipo_str	Repositorios
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Cytotoxicity of Copper Ions Released from Metal : Variation with the Exposure Period and Concentration Gradients

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