Effect of vanadium compounds on acid phosphatase activity

The direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of...

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Detalles Bibliográficos
Autores principales: Vescina, Cecilia M., Sálice, Viviana C., Cortizo, Ana María, Etcheverry, Susana B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 1996
Materias:
Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/76255
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-76255
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
spellingShingle Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
Vescina, Cecilia M.
Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
Effect of vanadium compounds on acid phosphatase activity
topic_facet Ciencias Exactas
Química
Vanadio
vanadium, acid phosphatase, tyrosine-phosphatase, fibroblast cells, inhibitory effects
description The direct effect of different vanadium compounds on acid phosphatase (ACP) activity was investigated. Vanadate and vanadyl but not pervanadate inhibited the wheat germ ACP activity. These vanadium derivatives did not alter the fibroblast Swiss 3T3 soluble fraction ACP activity. Using inhibitors of tyrosine phosphatases (PTPases), the wheat germ ACP was partially characterized as a PTPase. This study suggests that the inhibitory ability of different vanadium derivatives to modulate ACP activity seems to depend on the geometry around the vanadium atom more than on the oxidation state. Our results indicate a correlation between the PTPase activity and the sensitivity to vanadate and vanadyl cation.
format Articulo
Articulo
author Vescina, Cecilia M.
Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
author_facet Vescina, Cecilia M.
Sálice, Viviana C.
Cortizo, Ana María
Etcheverry, Susana B.
author_sort Vescina, Cecilia M.
title Effect of vanadium compounds on acid phosphatase activity
title_short Effect of vanadium compounds on acid phosphatase activity
title_full Effect of vanadium compounds on acid phosphatase activity
title_fullStr Effect of vanadium compounds on acid phosphatase activity
title_full_unstemmed Effect of vanadium compounds on acid phosphatase activity
title_sort effect of vanadium compounds on acid phosphatase activity
publishDate 1996
url http://sedici.unlp.edu.ar/handle/10915/76255
work_keys_str_mv AT vescinaceciliam effectofvanadiumcompoundsonacidphosphataseactivity
AT salicevivianac effectofvanadiumcompoundsonacidphosphataseactivity
AT cortizoanamaria effectofvanadiumcompoundsonacidphosphataseactivity
AT etcheverrysusanab effectofvanadiumcompoundsonacidphosphataseactivity
bdutipo_str Repositorios
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