High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet

The aim of this work was to determine the effect of a fructose rich diet (FRD) consumed by the pregnant mother on the endocrine-metabolic and in vivo and in vitro adipose tissue (AT) functions of the male offspring in adulthood. At 60 days of age, rats born to FRD-fed mothers (F) showed impaired glu...

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Detalles Bibliográficos
Autores principales: Alzamendi, Ana, Zubiría, María Guillermina, Moreno, Griselda, Portales, Andrea Estefanía, Spinedi, Eduardo Julio, Giovambattista, Andrés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Ciencias Médicas
Tejido Adiposo
Desnutrición
metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/75626
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-75626
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Tejido Adiposo
Desnutrición
metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome
spellingShingle Ciencias Médicas
Tejido Adiposo
Desnutrición
metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome
Alzamendi, Ana
Zubiría, María Guillermina
Moreno, Griselda
Portales, Andrea Estefanía
Spinedi, Eduardo Julio
Giovambattista, Andrés
High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
topic_facet Ciencias Médicas
Tejido Adiposo
Desnutrición
metabolic programming; adipocyte precursor cells; dysfunctional adipose tissue; altered glucose tolerance; insulin resistance; pre-diabetes; metabolic syndrome
description The aim of this work was to determine the effect of a fructose rich diet (FRD) consumed by the pregnant mother on the endocrine-metabolic and in vivo and in vitro adipose tissue (AT) functions of the male offspring in adulthood. At 60 days of age, rats born to FRD-fed mothers (F) showed impaired glucose tolerance after glucose overload and high circulating levels of leptin (LEP). Despite the diminished mass of retroperitoneal AT, this tissue was characterized by enhanced LEP gene expression, and hypertrophic adipocytes secreting in vitro larger amounts of LEP. Analyses of stromal vascular fraction composition by flow cytometry revealed a reduced number of adipocyte precursor cells. Additionally, 60 day-old control (C) and F male rats were subjected to control diet (CC and FC animals) or FRD (CF and FF rats) for three weeks. FF animals were heavier and consumed more calories. Their metabolic-endocrine parameters were aggravated; they developed severe hyperglycemia, hypertriglyceridemia, hyperleptinemia and augmented AT mass with hypertrophic adipocytes. Our study highlights that manipulation of maternal diet induced an offspring phenotype mainly imprinted with a severely unhealthy adipogenic process with undesirable endocrine-metabolic consequences, putting them at high risk for developing a diabetic state.
format Articulo
Articulo
author Alzamendi, Ana
Zubiría, María Guillermina
Moreno, Griselda
Portales, Andrea Estefanía
Spinedi, Eduardo Julio
Giovambattista, Andrés
author_facet Alzamendi, Ana
Zubiría, María Guillermina
Moreno, Griselda
Portales, Andrea Estefanía
Spinedi, Eduardo Julio
Giovambattista, Andrés
author_sort Alzamendi, Ana
title High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
title_short High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
title_full High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
title_fullStr High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
title_full_unstemmed High Risk of Metabolic and Adipose Tissue Dysfunctions in Adult Male Progeny, Due to Prenatal and Adulthood Malnutrition Induced by Fructose Rich Diet
title_sort high risk of metabolic and adipose tissue dysfunctions in adult male progeny, due to prenatal and adulthood malnutrition induced by fructose rich diet
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/75626
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