Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

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A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity a...

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Detalles Bibliográficos
Autores principales: Echeverría, María Gabriela, Pardini, Oscar Ricardo, Debandi, María Valeria, François, Nora Judit, Daraio, Marta Edith, Amalvy, Javier Ignacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/75587
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.

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