Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications

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A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity a...

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Autores principales: Echeverría, María Gabriela, Pardini, Oscar Ricardo, Debandi, María Valeria, François, Nora Judit, Daraio, Marta Edith, Amalvy, Javier Ignacio
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/75587
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-75587
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
spellingShingle Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
Echeverría, María Gabriela
Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
topic_facet Ingeniería Química
poliuretanos, sistemas de liberación de medicamentos, teofilina
polyurethanes, drug delivery systems, stimuli-sensitive polymers, swelling, theophylline
description A pH-sensitive blend of polyurethane (PU) and poly(2-(diethyl amino)ethyl methacrylate (PDEA) with good film‑forming capacity was prepared from the corresponding aqueous dispersions. The polymer matrix was first characterized by using FTIR, DSC, water vapor transmission and water swelling capacity at different pHs. The drug release profile of films was evaluated using a vertical Franz Cell and theophylline as model drug. The water swelling degree increases from 54 to 180% when the pH of the medium is changed from 6 to 2, demonstrating the pH-responsive behavior of the film. The in-vitro release studies indicate that an anomalous transport mechanism governs the theophylline release.
format Articulo
Articulo
author Echeverría, María Gabriela
Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
author_facet Echeverría, María Gabriela
Pardini, Oscar Ricardo
Debandi, María Valeria
François, Nora Judit
Daraio, Marta Edith
Amalvy, Javier Ignacio
author_sort Echeverría, María Gabriela
title Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_short Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_fullStr Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_full_unstemmed Polyurethane/Poly(2-(Diethyl Amino)Ethyl Methacrylate) blend for drug delivery applications
title_sort polyurethane/poly(2-(diethyl amino)ethyl methacrylate) blend for drug delivery applications
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/75587
work_keys_str_mv AT echeverriamariagabriela polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
AT pardinioscarricardo polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
AT debandimariavaleria polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
AT francoisnorajudit polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
AT daraiomartaedith polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
AT amalvyjavierignacio polyurethanepoly2diethylaminoethylmethacrylateblendfordrugdeliveryapplications
bdutipo_str Repositorios
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