Photosensitization of peptides and proteins by pterin derivatives

Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological cond...

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Detalles Bibliográficos
Autores principales: Dántola, María Laura, Reid, Lara Olivia, Castaño, Carolina, Lorente, Carolina, Oliveros, Esther, Thomas, Andrés Héctor
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/74893
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-74893
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
spellingShingle Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
Dántola, María Laura
Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
Photosensitization of peptides and proteins by pterin derivatives
topic_facet Ciencias Exactas
Química
Pteridinas
electron transfer; photosensitization; proteins; pterins; UV-A radiation
description Proteins are one of the preferential targets of the photosensitized damaging effects of ultraviolet (UV) radiation on biological system. Pterins belong to a family of heterocyclic compounds, which are widespread in living systems and participate in relevant biological functions. In pathological conditions, such as vitiligo, oxidized pterins accumulate in the white skin patches of patients suffering this depigmentation disorder. It is known that pterins are able to photosensitize damage in nucleotides and DNA by type I (electron transfer) and type II (singlet oxygen) mechanisms. Recently, it has been demonstrated that proteins and its components may also be damaged when solutions containing both proteins and pterin are exposed to UV-A radiation. Therefore, given the biological and medical relevance of the photosensitizing properties of these molecules, we present in this article an overview of the capability of different pterin derivatives to photoinduce damage in proteins present in the skin, focusing our attention on the chemical modifications of tyrosine and tryptophan residues.
format Articulo
Articulo
author Dántola, María Laura
Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
author_facet Dántola, María Laura
Reid, Lara Olivia
Castaño, Carolina
Lorente, Carolina
Oliveros, Esther
Thomas, Andrés Héctor
author_sort Dántola, María Laura
title Photosensitization of peptides and proteins by pterin derivatives
title_short Photosensitization of peptides and proteins by pterin derivatives
title_full Photosensitization of peptides and proteins by pterin derivatives
title_fullStr Photosensitization of peptides and proteins by pterin derivatives
title_full_unstemmed Photosensitization of peptides and proteins by pterin derivatives
title_sort photosensitization of peptides and proteins by pterin derivatives
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/74893
work_keys_str_mv AT dantolamarialaura photosensitizationofpeptidesandproteinsbypterinderivatives
AT reidlaraolivia photosensitizationofpeptidesandproteinsbypterinderivatives
AT castanocarolina photosensitizationofpeptidesandproteinsbypterinderivatives
AT lorentecarolina photosensitizationofpeptidesandproteinsbypterinderivatives
AT oliverosesther photosensitizationofpeptidesandproteinsbypterinderivatives
AT thomasandreshector photosensitizationofpeptidesandproteinsbypterinderivatives
bdutipo_str Repositorios
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