Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillu...

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Detalles Bibliográficos
Autores principales: Zubiría, María Guillermina, Gambaro, Sabrina Eliana, Rey, María Amanda, Carasi, Paula, Serradell, María de los Ángeles, Giovambattista, Andrés
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Exactas
gut microbiota; fructose-rich diet; adipose tissue; probiotics
Fructosa
Probióticos
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/73865
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-73865
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
gut microbiota; fructose-rich diet; adipose tissue; probiotics
Fructosa
Probióticos
spellingShingle Ciencias Exactas
gut microbiota; fructose-rich diet; adipose tissue; probiotics
Fructosa
Probióticos
Zubiría, María Guillermina
Gambaro, Sabrina Eliana
Rey, María Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andrés
Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
topic_facet Ciencias Exactas
gut microbiota; fructose-rich diet; adipose tissue; probiotics
Fructosa
Probióticos
description Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.
format Articulo
Articulo
author Zubiría, María Guillermina
Gambaro, Sabrina Eliana
Rey, María Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andrés
author_facet Zubiría, María Guillermina
Gambaro, Sabrina Eliana
Rey, María Amanda
Carasi, Paula
Serradell, María de los Ángeles
Giovambattista, Andrés
author_sort Zubiría, María Guillermina
title Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
title_short Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
title_full Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
title_fullStr Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
title_full_unstemmed Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration
title_sort deleterious metabolic effects of high fructose intake: the preventive effect of lactobacillus kefiri administration
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/73865
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