Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed

Equine arteritis virus infection in horse populations could be confirmed by the OIE recommended Virus Neutralization (VN) test and by the gold standard Virus Isolation (VI). These two techniques involve the observation of the cytopathic effect (CPE) of EAV. The characteristic CPE in...

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Autores principales:	Abeyá, María Mercedes, Metz, Germán Ernesto, Franco Cruz, Rodrigo, Correas, Ignacio, Osorio, Fernando, Echeverría, María Gabriela
Formato:	Articulo Comunicacion
Lenguaje:	Inglés
Publicado:	2018
Materias:	Ciencias Veterinarias equinos infecciones virales equine arteritis virus cytopathic effect caspase-dependent cell death
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/68155 http://medcraveonline.com/JMEN/JMEN-06-00210.pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-68155
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Veterinarias equinos infecciones virales equine arteritis virus cytopathic effect caspase-dependent cell death
spellingShingle	Ciencias Veterinarias equinos infecciones virales equine arteritis virus cytopathic effect caspase-dependent cell death Abeyá, María Mercedes Metz, Germán Ernesto Franco Cruz, Rodrigo Correas, Ignacio Osorio, Fernando Echeverría, María Gabriela Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
topic_facet	Ciencias Veterinarias equinos infecciones virales equine arteritis virus cytopathic effect caspase-dependent cell death
description	Equine arteritis virus infection in horse populations could be confirmed by the OIE recommended Virus Neutralization (VN) test and by the gold standard Virus Isolation (VI). These two techniques involve the observation of the cytopathic effect (CPE) of EAV. The characteristic CPE in EAV infections is the cellular lysis. The presence/absence of this CPE in cells in the VI/VN respectively, indicate the positivity of each test. CPE refers to morphological and molecular changes that where evidence in infect cells after viral infections. Most viral infections eventually result in the death of the host cell by different cellular mechanisms. The causes of death include cell lysis by alterations to the cell’s surface membrane and by various modes of programmed cell death such as necrosis, apoptosis, autophagy and others. EAV CPE is always refers as cellular lysis but the mechanism involve in this lytical effect has never specifically determined. So, our objective is to extend the concept of the cytopathic effect of EAV infections. To study the effect of different cell death mechanism in EAV CPE we used different inhibitors. Consequently, we concluded that the most important mechanism of cell death in EAV infections is caspase-dependent cell death.
format	Articulo Comunicacion
author	Abeyá, María Mercedes Metz, Germán Ernesto Franco Cruz, Rodrigo Correas, Ignacio Osorio, Fernando Echeverría, María Gabriela
author_facet	Abeyá, María Mercedes Metz, Germán Ernesto Franco Cruz, Rodrigo Correas, Ignacio Osorio, Fernando Echeverría, María Gabriela
author_sort	Abeyá, María Mercedes
title	Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
title_short	Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
title_full	Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
title_fullStr	Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
title_full_unstemmed	Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
title_sort	equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed
publishDate	2018
url	http://sedici.unlp.edu.ar/handle/10915/68155 http://medcraveonline.com/JMEN/JMEN-06-00210.pdf
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bdutipo_str	Repositorios
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Equine arteritis virus cytopathic effect: caspase-dependent cell death as the major consequence observed

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