Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction

Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with piogl...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alzamendi, Ana, Giovambattista, Andrés, García, María Elisa, Rebolledo, Oscar Remigio, Gagliardino, Juan José, Spinedi, Eduardo
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2012
Materias:	Medicina Microbiología Adiposidad Fructosa fructose rich diet, endocrine abdominal tissue dysfunction
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/68072 https://www.hindawi.com/journals/ppar/2012/259093/
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-68072
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Medicina Microbiología Adiposidad Fructosa fructose rich diet, endocrine abdominal tissue dysfunction
spellingShingle	Medicina Microbiología Adiposidad Fructosa fructose rich diet, endocrine abdominal tissue dysfunction Alzamendi, Ana Giovambattista, Andrés García, María Elisa Rebolledo, Oscar Remigio Gagliardino, Juan José Spinedi, Eduardo Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
topic_facet	Medicina Microbiología Adiposidad Fructosa fructose rich diet, endocrine abdominal tissue dysfunction
description	Aim. To test the potential role of PPARγ in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate- (IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPARγ would play a relevant role in the development of the FRD-induced metabolicendocrine dysfunction.
format	Articulo Articulo
author	Alzamendi, Ana Giovambattista, Andrés García, María Elisa Rebolledo, Oscar Remigio Gagliardino, Juan José Spinedi, Eduardo
author_facet	Alzamendi, Ana Giovambattista, Andrés García, María Elisa Rebolledo, Oscar Remigio Gagliardino, Juan José Spinedi, Eduardo
author_sort	Alzamendi, Ana
title	Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
title_short	Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
title_full	Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
title_fullStr	Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
title_full_unstemmed	Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction
title_sort	effect of pioglitazone on the fructose-induced abdominal adipose tissue dysfunction
publishDate	2012
url	http://sedici.unlp.edu.ar/handle/10915/68072 https://www.hindawi.com/journals/ppar/2012/259093/
work_keys_str_mv	AT alzamendiana effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction AT giovambattistaandres effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction AT garciamariaelisa effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction AT rebolledooscarremigio effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction AT gagliardinojuanjose effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction AT spinedieduardo effectofpioglitazoneonthefructoseinducedabdominaladiposetissuedysfunction
bdutipo_str	Repositorios
_version_	1764820483131310083

Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue Dysfunction

Ejemplares similares