Vanadium Compounds : Their Action on Alkaline Phosphatase Activity

The direct effect of different vanadium compounds upon alkaline phosphatase (ALP) activity was investigated~ Vanadate and vanadyl inhibited both the soluble and particulate ALP activity from UMR.106 cells and front bovine intestinal ALP. We have also shown the inhibition of ALP activity in the solub...

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Detalles Bibliográficos
Autores principales: Cortizo, Ana María, Salice, Viviana C., Etcheverry, Susana B.
Formato: Articulo
Lenguaje:Inglés
Publicado: 1994
Materias:
Ciencias Médicas
vanadium, alkaline phosphatase, tyrosine-phosphatase, osteoblast cells, bone cells, inhibitory effects
Vanadio
Fosfatasa Alcalina
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/67403
https://link.springer.com/article/10.1007%2FBF02917433
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-67403
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
vanadium, alkaline phosphatase, tyrosine-phosphatase, osteoblast cells, bone cells, inhibitory effects
Vanadio
Fosfatasa Alcalina
spellingShingle Ciencias Médicas
vanadium, alkaline phosphatase, tyrosine-phosphatase, osteoblast cells, bone cells, inhibitory effects
Vanadio
Fosfatasa Alcalina
Cortizo, Ana María
Salice, Viviana C.
Etcheverry, Susana B.
Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
topic_facet Ciencias Médicas
vanadium, alkaline phosphatase, tyrosine-phosphatase, osteoblast cells, bone cells, inhibitory effects
Vanadio
Fosfatasa Alcalina
description The direct effect of different vanadium compounds upon alkaline phosphatase (ALP) activity was investigated~ Vanadate and vanadyl inhibited both the soluble and particulate ALP activity from UMR.106 cells and front bovine intestinal ALP. We have also shown the inhibition of ALP activity in the soluble fraction of osteoblasts by peroxo and hydroperoxo vanadium compounds. ALP activity in the particulate fraction was not inhibited by these species; nor was the bovine intestinal ALP. Using inhibitors of Tyr-phosphatase (PTPases), the soluble ALP was partially characterized as a PTPase. The major activity in the particulate fraction represents the bone-specific ALPactivity. This study demonstrates that different forms of vanadium are direct inhibitors of ALP activity. This effect is dependent on the enzymatic activity investigated and on the origin of the ALP.
format Articulo
Articulo
author Cortizo, Ana María
Salice, Viviana C.
Etcheverry, Susana B.
author_facet Cortizo, Ana María
Salice, Viviana C.
Etcheverry, Susana B.
author_sort Cortizo, Ana María
title Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
title_short Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
title_full Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
title_fullStr Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
title_full_unstemmed Vanadium Compounds : Their Action on Alkaline Phosphatase Activity
title_sort vanadium compounds : their action on alkaline phosphatase activity
publishDate 1994
url http://sedici.unlp.edu.ar/handle/10915/67403
https://link.springer.com/article/10.1007%2FBF02917433
work_keys_str_mv AT cortizoanamaria vanadiumcompoundstheiractiononalkalinephosphataseactivity
AT salicevivianac vanadiumcompoundstheiractiononalkalinephosphataseactivity
AT etcheverrysusanab vanadiumcompoundstheiractiononalkalinephosphataseactivity
bdutipo_str Repositorios
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