Mining the biomedical literature to predict shared drug targets in drugbank
The current drug development pipelines are characterised by long processes with high attrition rates and elevated costs. More than 80% of new compounds fail in the later stages of testing due to severe side-effects caused by unknown biomolecular targets of the compounds. In this work, we present a m...
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| Autores principales: | , , |
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| Formato: | Objeto de conferencia |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/63201 http://www.clei2017-46jaiio.sadio.org.ar/sites/default/files/Mem/SLMDI/SLMDI-03.pdf |
| Aporte de: |
| Sumario: | The current drug development pipelines are characterised by long processes with high attrition rates and elevated costs. More than 80% of new compounds fail in the later stages of testing due to severe side-effects caused by unknown biomolecular targets of the compounds. In this work, we present a measure that can predict shared targets for drugs in DrugBank through large scale analysis of the biomedical literature. We show that using MeSH ontology terms can accurately describe the drugs and that appropriate use of the MeSH ontological structure can determine pairwise drug similarity. |
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